[MOS] March 24, 2009

[Zina Queen]

Seminar on

Modern Optics and Spectroscopy

Detecting cervical dysplasia with quantitative spectroscopic imaging

Condon Lau, MIT

Tuesday, March 24, 2009
Grier Room 34-401


12:00 - 1:00 p.m.

We use Quantitative Spectroscopic Imaging (QSI) to study patients 
referred for colposcopy or Loop Electrosurgical Excision Procedure to 
identify high-grade squamous intraepithelial lesions (HSIL) in 
cervical transformation zone. To accomplish this, we normalize 
spectroscopy measurements and utilize the spatial continuity of HSIL 
to improve accuracy. Results from the study show that sites 
determined to be HSIL by QSI are in good agreement with pathology. 
Furthermore, the diagnostic criteria are independent of 
instrumentation. QSI can improve early cancer detection in the cervix 
and has the potential to be inexpensiveand easy to use, making it 
suitable for applications in developed and developing countries.


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