[MOS] November 6, 2007

[Zina Queen]

Seminar on
Modern Optics and Spectroscopy


Stephen Coy,
Sionex Corporation

The power of differential ion mobility

November 6, 2007

12:00 - 1:00 p.m.
Grier Room 34-401



Ion mobility spectrometry is an active area of current research and 
device development with over 100 related publications so far in 2007 
alone. Ion mobility techniques share simplicity, speed, and a range 
of scientific and analytical capabilities, The richness of ion 
response to static and dynamic electric fields in gases at near 
atmospheric pressure is exploited to separate mixtures of ion species 
from 19 Da to 30 kDa and higher. Separation is based on properties 
including ion conformation, structural rigidity, clustering affinity, 
field alignment, and geometric profiles. Structural isomers, isobaric 
compounds, and even racemic mixtures can be resolved. Very high field 
techniques like Differential Mobility Spectrometry (DMS / planar 
FAIMS) also reveal unimolecular decomposition and reaction processes 
similar to CID in mass spectrometry. In biological, pharmaceutical, 
and diagnostic applications, DMS-prefiltered mass spectrometry 
separates species in complex mixtures in milliseconds, and can often 
replace LC techniques taking much longer.
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