<!doctype html public "-//W3C//DTD W3 HTML//EN">
<html><head><style type="text/css"><!--
blockquote, dl, ul, ol, li { padding-top: 0 ; padding-bottom: 0 }
--></style><title>November 6, 2007</title></head><body>
<div><font face="Arial" color="#000000">Seminar on<br>
<b>Modern Optics and Spectroscopy<br>
<br>
<br>
Stephen Coy</b>,<br>
Sionex Corporation<br>
<br>
<i><b>The power of differential ion mobility<br>
<br>
</b></i>November 6, 2007<br>
<br>
12:00 - 1:00 p.m.</font></div>
<div><font face="Arial" color="#000000">Grier Room 34-401<br>
</font><font face="Times"
color="#000000"><x-tab>
</x-tab><br>
<br>
<br>
</font><font face="Times New Roman" color="#000000">Ion mobility
spectrometry is an active area of current research and device
development with over 100 related publications so far in 2007 alone.
Ion mobility techniques share simplicity, speed, and a range of
scientific and analytical capabilities, The richness of ion response
to static and dynamic electric fields in gases at near atmospheric
pressure is exploited to separate mixtures of ion species from 19 Da
to 30 kDa and higher. Separation is based on properties including ion
conformation, structural rigidity, clustering affinity, field
alignment, and geometric profiles. Structural isomers, isobaric
compounds, and even racemic mixtures can be resolved. Very high field
techniques like Differential Mobility Spectrometry (DMS / planar
FAIMS) also reveal unimolecular decomposition and reaction processes
similar to CID in mass spectrometry. In biological, pharmaceutical,
and diagnostic applications, DMS-prefiltered mass spectrometry
separates species in complex mixtures in milliseconds, and can often
replace LC techniques taking much longer.</font></div>
</body>
</html>