[bioundgrd] Fwd: Co-op Position at Genentech Inc: San Francisco

[MacKenzie Outlund]

---------- Forwarded message ----------
From: Hirdesh Uppal <uppal.hirdesh at gene.com>
Subject: Co-op Position at Genentech Inc: San Francisco


*Position Details:*



We are seeking a Co-op/Internship candidate (6 month or longer position) in
Genentech Development Sciences for conducting and overseeing scientific
investigations and screening activities to support a project using stem
cells for generation of functional hepatocytes.  Various cell types have
been generated in vitro from stem cells via defined and stepwise
differentiation through the recapitulation of appropriate developmental
steps with stage- and lineage-specific modulators (e.g. cytokines and small
molecules).  The specific aims of our project are focused on identifying
small molecules that can mimic the signal requirement during direct
differentiation of stem cell into functionally competent and metabolically
active hepatocytes.  Utilizing stem cells the co-op candidate will screen
against a focused as well as large chemical library in order to identify
small molecules which cause generation of functionally competent hepatocytes
having an adult hepatocyte phenotype.  The application of such a model will
be wide ranging: improved hepatocyte models for drug discovery programs,
enhanced drug metabolism prediction, and optimized tools for mechanistic
understanding of safety liabilities encountered during small molecule drug
development.  This position will enable the co-op student to participate in
a high impact project related to stem cell technologies.  In addition based
on the research outcomes and individual contribution, the project will
provide an opportunity to participate at a national level meeting and
publish the results.



Contact:

--------------------------------

Hirdesh Uppal, DVM, PhD.

Development Sciences,

Genentech, Inc.

1 DNA Way, MS#59

South San Francisco, CA 94080

Email: hirdeshu at gene.com

Tel: 650-225-7180
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