[bioundgrd] UROP opening

[Rachel McPherson]

UROP Department/Lab/Center: Broad Inst
Faculty Supervisor: James Bradner, MD
Project Title:

Small molecule inhibitors of the Histone 
Deacetylase family of enzymes and their role in 
cancer biology

Project Description:

The Bradner group is a small division of the 
Broad Chemical Biology program, directed by Prof. 
Stuart Schreiber. We use a variety of 
experimental techniques, including 
high-throughput cell based screening assays, to 
probe the function of the histone deacetylase 
(HDAC) family of proteins. Our research includes 
translational projects with the goal of immediate 
improvement in the treatment of cancer patients 
as well as more traditional academic 
investigation. Specifically we are investigating 
the role of HDAC 6 in aggresome mediated 
degradation of ubiquitinated proteins, 
collaborating with synthetic chemists to develop 
more potent and selective inhibitors of HDAC 6 
for application in cancer treatment, and 
developing a high-throughput screen to discover 
novel small molecule inducers and inhibitors of 
autophagy. We are looking for an undergraduate 
student with background experience in biology 
and/or chemistry to join our team, learn our 
techniques, with the eventual goal of piloting 
his/her own project. Because our lab is led by a 
physician scientist this position would be ideal 
for a student planning on pursuing a MD or 
M.D./Ph.D. degree. Physically this research would 
take place at the new Broad research building, 7 
Cambridge Center, across the street from building 
68.

Prerequisites:

We would like a student to work part time during 
the spring semester and then full time over the 
summer. Prior lab and classroom experience in 
biology and/or chemistry is ideal.

Contact:

If interested please e-mail a resume to: 
<mailto:jpshen at wustl.edu>jpshen at wustl.edu
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