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<div><tt>UROP Department/Lab/Center: Broad Inst</tt></div>
<div><tt>Faculty Supervisor: James Bradner, MD</tt></div>
<div><tt>Project Title:</tt></div>
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<div>Small molecule inhibitors of the Histone Deacetylase family of
enzymes and their role in cancer biology</div>
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<div><tt>Project Description:</tt></div>
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<div>The Bradner group is a small division of the Broad Chemical
Biology program, directed by Prof. Stuart Schreiber. We use a variety
of experimental techniques, including high-throughput cell based
screening assays, to probe the function of the histone deacetylase
(HDAC) family of proteins. Our research includes translational
projects with the goal of immediate improvement in the treatment of
cancer patients as well as more traditional academic investigation.
Specifically we are investigating the role of HDAC 6 in aggresome
mediated degradation of ubiquitinated proteins, collaborating with
synthetic chemists to develop more potent and selective inhibitors of
HDAC 6 for application in cancer treatment, and developing a
high-throughput screen to discover novel small molecule inducers and
inhibitors of autophagy. We are looking for an undergraduate student
with background experience in biology and/or chemistry to join our
team, learn our techniques, with the eventual goal of piloting his/her
own project. Because our lab is led by a physician scientist this
position would be ideal for a student planning on pursuing a MD or
M.D./Ph.D. degree. Physically this research would take place at the
new Broad research building, 7 Cambridge Center, across the street
from building 68.</div>
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<div><tt>Prerequisites:</tt></div>
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<div>We would like a student to work part time during the spring
semester and then full time over the summer. Prior lab and classroom
experience in biology and/or chemistry is ideal.</div>
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<div><tt>Contact:</tt></div>
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<div>If interested please e-mail a resume to: <a
href="mailto:jpshen@wustl.edu">jpshen@wustl.edu</a></div>
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