[MOS] 3/6 - Modern Optics and Spectroscopy Seminar with Joerg Bewersdorf, Yale University

[Christine Brooks]

There will be a Modern Optics and Spectroscopy Seminar held tomorrow, Tuesday, March 6 at 12pm in NE47-189

**Please note location**

Joerg Bewersdorf
Yale University

“3D and live-cell multicolor super-resolution microscopy for cell biological research”

Cell biological research relies heavily on the capabilities of light microscopes to resolve structures or processes of interest [1]. My research group is developing super-resolution technology that pushes these capabilities in particular with respect to 3D resolution, speed, live-cell compatibility and depth penetration. In this presentation, I will report on my lab’s recent progress on imaging whole cells at sub-20 nm 3D resolution and on live-cell imaging at 50 nm resolution and below. I will summarize published work [2, 3] as well as present recent, unpublished results. Technology and method development will be present in the context of cell biological applications and discoveries.

[1] D. Baddeley, J. Bewersdorf “Biological Insight from Super-Resolution Microscopy: What We Can Learn from Localization-Based Images”, Annu. Rev. Biochem 2018, in press http://www.annualreviews.org/doi/abs/10.1146/annurev-biochem-060815-014801

[2] F. Huang, G. Sirinakis, E.S. Allgeyer, L.K. Schroeder, W.C. Duim, E.B. Kromann, T. Phan, F.E. Rivera-Molina, J.R. Myers, I. Irnov, M. Lessard, Y. Zhang, M.A. Handel, C. Jacobs-Wagner, C.P. Lusk, J.E. Rothman, D.K. Toomre, M.J. Booth, J. Bewersdorf “Ultra-high resolution 3D imaging of whole cells”, Cell 2016 http://www.cell.com/cell/fulltext/S0092-8674(16)30745-0

[3] F. Bottanelli, E.B. Kromann, E.S. Allgeyer, R.S. Erdmann, S. Wood Baguley, G. Sirinakis, A. Schepartz, D. Baddeley, D.K. Toomre, J.E. Rothman, J. Bewersdorf “Two-colour live-cell nanoscale imaging of intracellular targets”, Nature Communication 2016 https://www.nature.com/articles/ncomms10778

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Refreshments will be served immediately following the seminar


Christine Brooks
Administrative Assistant
Massachusetts Institute of Technology
Department of Chemistry
77 Massachusetts Ave, 6-333
Cambridge, MA 02139
p: 617.253.7239
e: cbrooks at mit.edu<mailto:cbrooks at mit.edu>

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