[MOS] March 11, 2014, Tayyaba Hasan, Wellman Center, Massachusetts General Hospital

[Zina M Queen]

Seminar on 

Modern Optics and Spectroscopy

 

Photodynamic Therapy:  A bridge between Science, Technology, and Medicine

 

Tayyaba Hasan,

Wellman Center,

Massachusetts General Hospital

Tuesday, March 11, 2014

12:00 – 1:00 p.m.

 Absorption of light by chromophores within or associated with, cells and tissues creates photophysical processes that are captured for diagnostic and/or surgical guidance, treatment of simple mechanistic understanding of disease pathology. Photodynamic therapy (PDT) is a photochemistry based process resulting from the light activation of chemicals localized at anatomical sites of disease. The active molecular species produced by the molecular excited state destroys biological targets in the vicinity. PDT is approved for specific clinical applications by regulatory agencies world wide. A small fraction of the excited state de-energizes via fluorescence thus providing an opportunity to use the same molecule for detection/diagnostics and therapy. As with any therapy, PDT elicits molecular responses, the scientific understanding of which can be exploited to enrich our arsenal of cancer treatment. Often this requires the development of new delivery systems and new chemical technologies. Visualizing the localization of these new constructs requires advances and adaptations in optical methods and engineering. The presentation will discuss how these different aspects of science and engineering have advanced PDT to its current state as a theranostic modality and speculate on future directions.


Grier Room, MIT Bldg 34-401

Refreshments served after the lecture
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