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<!--StartFragment--><p class="MsoTitle" style="text-align: center;margin-right: -0.5in; "><b><span style="font-family:"Times New Roman""><font size="4">Seminar on</font></span></b><b><span style="font-family: 'Times New Roman'; "><font size="4"> </font></span></b></p><p class="MsoNormal" align="center" style="text-align:center"><font size="4"><b><span style="letter-spacing: 1.5pt; ">Modern Optics and Spectroscopy</span></b><span style="font-family:Arial;
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Center, <o:p></o:p></font></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font size="4">Massachusetts
General Hospital<o:p></o:p></font></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-size: large; letter-spacing: 1pt; ">Tuesday,
March 11, 2014</span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font size="4">12:00 –
1:00 p.m.<o:p></o:p></font></span></p>
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<!--StartFragment--><p class="MsoNormal" style="text-align:justify"><font size="4"> Absorption of light by chromophores within or
associated with, cells and tissues creates photophysical processes that are
captured for diagnostic and/or surgical guidance, treatment of simple
mechanistic understanding of disease pathology. Photodynamic therapy (PDT) is a
photochemistry based process resulting from the light activation of chemicals
localized at anatomical sites of disease. The active molecular species produced
by the molecular excited state destroys biological targets in the vicinity. PDT
is approved for specific clinical applications by regulatory agencies world
wide. A small fraction of the excited state de-energizes via fluorescence thus
providing an opportunity to use the same molecule for detection/diagnostics and
therapy. As with any therapy, PDT elicits molecular responses, the scientific
understanding of which can be exploited to enrich our arsenal of cancer
treatment. Often this requires the development of new delivery systems and new
chemical technologies. Visualizing the localization of these new constructs requires
advances and adaptations in optical methods and engineering. The presentation
will discuss how these different aspects of science and engineering have
advanced PDT to its current state as a theranostic modality and speculate on
future directions.<o:p></o:p></font></p>
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<!--StartFragment--><p class="MsoNormal" align="center" style="text-align:center"><font size="4">Grier Room, MIT Bldg 34-401<o:p></o:p></font></p><p class="MsoNormal" align="center" style="text-align:center"><font size="4">Refreshments served after
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