[MOS] April 15, 2014, Christopher Rowland, Massachusetts Institute of Technology

[Zina M Queen]

Seminar on 

Modern Optics and Spectroscopy 

Big Lasers and Biology-Treating Cancer and mapping the Connectome with light 

Christopher Rowland,

Massachusetts Institute of Technology 

Tuesday, April 15, 2014 

12:00 – 1:00 p.m.

Many optical techniques such as multiphoton microscopy and super-resolution microscopy provide unique capabilities to both image and pattern biological samples, yet remain impractically slow for many users. This presentation will describe two different projects in which parallelization is exploited in order to achieve several orders of magnitude increase in speed; a capability that is only possible due to the development of new high-power lasers and optical amplifiers. The first part of the presentation will focus on 3D-resolved cell killing using multiphoton excitation and photodynamic therapy, showing that individual cancer cells can be targeted and killed without significantly affecting the surrounding cells, and that areas of approximately one square millimeter can be patterned with exposure times on the order of seconds. The next part of the presentation will describe efforts to create a microscope that can image the mouse brain with 50nm 3D spatial resolution at a gigapixel per second; progress towards this ambitious goal will be demonstrated.  

Grier Room, MIT Bldg 34-401

Refreshments served after the lecture
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