[Crib-list] SPEAKER: Adam Riesselman (Harvard) | Computational Research in Boston and Beyond Seminar (CRIBB) | Friday, 05/04/2018 | 12:00 PM - 1:00 PM | Building 32, Room 124 (STATA)

[daisymae@mit.edu]

 	       Computational Research in Boston and Beyond Seminar
 				   (CRIBB)



DATE:		Friday, May 4, 2018

TIME:		12:00 Noon to 1:00 PM

LOCATION:	Building 32, Room 124  (STATA)
 		    32 Vassar Street
 		    Cambridge, MA

 		   (Pizza/beverages will be provided at 11:45 AM outside
 		   Room 32-124)


TITLE:		Predicting the effect of mutations with generative models
 		of evolutionary sequences



SPEAKER:	Adam Riesselman  (Harvard University)


ABSTRACT:

Modern genome sequencing and synthesis can acquire and generate tremendous 
molecular diversity in a day, but our ability to navigate and interpret 
the exponentially large space of potential biological sequences remains 
limited.  Central to this challenge is the lack of a priori knowledge 
about epistasis, i.e. non-additive interactions between positions in a 
molecule or genome.  I will describe how generative models fit to 
evolutionary sequences can be used to help explain these factors.  I will 
then discuss two classes of generative models, discrete undirected 
graphical models and neural-network powered latent variable models, which 
can reveal the three dimensional structures and mutational landscapes of 
proteins and RNA solely from evolutionary information.



===================================================================

Massachusetts Institute of Technology
Cambridge, MA


For information about the Computational Research in Boston and Beyond Seminar 
(CRIBB), please visit....

 			http://math.mit.edu/crib/



===

Shirley A. Entzminger
Administrative Assistant II
Department of Mathematics
Massachusetts Institute of Technology
77 Massachusetts Avenue
Building 2, Room 350A
Cambridge, MA 02139
PHONE:	(617) 253-4347
FAX:	(617) 253-4358
E-mail:	daisymae at math.mit.edu
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