[Crib-list] TODAY: SPEAKER: Mukarram Tahir (MIT) | CRIBB Seminar | Friday, April 7, 2017 | TIME: 12:00 PM - 1:00 PM | Building 32, Room 155

[Shirley Entzminger]

 	T O D A Y . . .


 		   COMPUTATIONAL RESEARCH in BOSTON and BEYOND Seminar


DATE:		Friday, April 7, 2017
TIME:		12:00 PM  1:00 PM
LOCATION:	Building 32, Room 155  (STATA)
 		   (32 Vassar Street, Cambridge)

     Pizza and beverages will be provided at 11:45 AM outside Room 32-155.



TITLE:		Molecular design of protein-mimetic nanostructures


SPEAKER:	MUKARRAM A. TAHIR  (Massachusetts Institute of Technology)


ABSTRACT:

Gold nanoparticles functionalized with an amphiphilic monolayer of alkanethiol 
ligands can insert into lipid membranes through a non-disruptive pathway that 
has been well-characterized using a combination of experiments and atomistic 
molecular dynamics simulations. The physiochemical similarity between these 
nanoparticles and amphiphilic membrane-bound and free-circulating proteins 
suggests a possibility for designing nanostructures that can function as 
biomimetic proteins. In this talk, I will present an overview of how molecular 
simulation techniques have allowed us to tackle this engineering challenge and 
develop nanoparticles that can modulate fusion between lipid membranes, 
transport hydrophobic small molecules to lipid-bound compartments, and induce 
transient curvature for sculpting lipid membranes into organelles. These 
studies point to a unique opportunity for utilizing monolayer-protected 
nanoparticles as a versatile platform for engineering targeted nano-bio 
interactions.




===================================================================

Massachusetts Institute of Technology
Cambridge, MA


For information about the Computational Research in Boston and Beyond Seminar, 
please visit...

 			http://math.mit.edu/crib/





===
Shirley A. Entzminger
Administrative Assistant II
Department of Mathematics
Massachusetts Institute of Technology
77 Massachusetts Avenue
Building 2, Room 350A
Cambridge, MA 02139
PHONE:	(617) 253-4347
FAX:	(617) 253-4358
E-mail:	daisymae at math.mit.edu

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