[Crib-list] SPEAKER: Mukarram Tahir (MIT) | CRIBB Seminar | Friday, April 7, 2017 | TIME: 12:00 PM - 1:00 PM | Building 32, Room 155

[Shirley Entzminger]

 		   COMPUTATIONAL RESEARCH in BOSTON and BEYOND Seminar


DATE:		Friday, April 7, 2017
TIME:		12:00 PM  1:00 PM
LOCATION:	Building 32, Room 155  (STATA)
 		  (32 Vassar Street, Cambridge)

     Pizza and beverages will be provided at 11:45 AM outside Room 32-155.



TITLE:		Molecular design of protein-mimetic nanostructures


SPEAKER:	MUKARRAM A. TAHIR  (Massachusetts Institute of Technology)


ABSTRACT:

Gold nanoparticles functionalized with an amphiphilic monolayer of 
alkanethiol ligands can insert into lipid membranes through a 
non-disruptive pathway that has been well-characterized using a 
combination of experiments and atomistic molecular dynamics simulations. 
The physiochemical similarity between these nanoparticles and amphiphilic 
membrane-bound and free-circulating proteins suggests a possibility for 
designing nanostructures that can function as biomimetic proteins. In this 
talk, I will present an overview of how molecular simulation techniques 
have allowed us to tackle this engineering challenge and develop 
nanoparticles that can modulate fusion between lipid membranes, transport 
hydrophobic small molecules to lipid-bound compartments, and induce 
transient curvature for sculpting lipid membranes into organelles. These 
studies point to a unique opportunity for utilizing monolayer-protected 
nanoparticles as a versatile platform for engineering targeted nano-bio 
interactions.




===================================================================

Massachusetts Institute of Technology
Cambridge, MA


For information about the Computational Research in Boston and Beyond Seminar, 
please visit...

 			http://math.mit.edu/crib/





===
Shirley A. Entzminger
Administrative Assistant II
Department of Mathematics
Massachusetts Institute of Technology
77 Massachusetts Avenue
Building 2, Room 350A
Cambridge, MA 02139
PHONE:	(617) 253-4347
FAX:	(617) 253-4358
E-mail:	daisymae at math.mit.edu

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