[bioundgrd] FW: MIT energy initiative Bioethanol project

[Joshua Stone]

From: Jean-Francois P Hamel <jhamel at mit.edu>
Subject: MIT energy initiative Bioethanol project

Dear Student,

I hope you are doing well in this last portion of the term.

In case you are available this summer and interested in the bioprocess engineering project described below, please send me a copy of your resume ASAP. Funding would come from the MIT Energy Initiative Office, if a proposal can be submitted by 5/13. The work can be part-time or full-time, and a portion of it could be done remotely. I am available daily for the remainder of the week to meet and help with the proposal production.
This project aims to develop a semi-batch yeast bioreactor process for making bioethanol, as efficiently as possible, and validate the process using online and off-line engineering and analytical tools.
Cell culture processes developed for production of therapeutics or biofuels can run for weeks, and it is not uncommon to see critical process parameters (CPP) deviate from the desired trajectories, following sensor failure (e.g., temperature, pH, dissolved oxygen) or because of the variability in raw materials and cells, from one bioreactor run to the other. Therefore, there is merit to monitor and control the bioprocess in real time, so that both CPP and process performance follow desirable trajectories against a run of reference (referred to the Golden Batch, in industry). Likewise, validating the bioprocess using a real-time mass balancing approach would create value in process understanding and facilitate the implementation of control algorithms. Constructing a real-time mass balance of a bioprocess is the overall mission of the project with a focus on the carbon flow, using online instrumentation, software models and data analytics.

Jean-François P. Hamel, PhD (he/him/his)
Director, Undergraduate Teaching Laboratories
Location: 66-0042 and E18-676
Office: 66-0005
Email: jhamel at mit.edu
Telephone: 617-258-6665




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