[bioundgrd] FW: Computational biology postgrad opportunity in my lab (Yale)

[Joshua Stone]

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From: "Braun, David" <david.braun at yale.edu<mailto:david.braun at yale.edu>>
Subject: Computational biology postgrad opportunity in my lab (Yale)
Date: January 24, 2022 at 5:37:37 PM EST

Postgraduate position computational biology / bioinformatics position in the Yale Cancer Center (Braun Lab)
The Braun Lab (Yale Center of Molecular and Cellular Oncology / Yale Cancer Center / Yale School of Medicine) is seeking a highly motivated, computationally-focused postgraduate with an interested in cancer immunotherapy and immunogenomics to join our translational research team.
Our laboratory aims to understand the key determinants of effective anti-tumor immunity, utilizing high-dimensional analytic tools and patient-derived models to study human tumors. We have focused our efforts on renal cell carcinoma (kidney cancer), and our work has helped to elucidate genetic and immunologic features that impact response to immune checkpoint inhibitors (Braun, Nature Medicine, 2020) and to define the immunologic changes that occur with progression to advanced disease (Braun, Cancer Cell, 2021). We now aim to understand the antigenic and immune microenvironmental features that determine why kidney cancers respond or a resistant to current immunotherapies, and to create patient-derived pre-clinical models to aid the development of novel immunotherapy approaches in this disease (Braun, Nature Reviews Clinical Oncology, 2021).
The ideal candidate will have a strong background in computer/data science (including statistics), knowledge of R and python, experience with high performance computing clusters, be collaborative in nature, an independent learning, be able to problem solve, and have outstanding oral and written communication skills.
1. Training: Postgraduates will develop skillsets in bulk and single-cell genomic analysis, the creation and maintenance of computational pipelines for immunogenomic analysis (including T cell receptor sequencing analysis and prediction of tumor antigens).
2. Mentoring: The BraunLab is committed to mentoring postgraduates, and the Principal Investigator (PI) has a track record of postgraduate mentees ultimately going to medical school or other professional schools. The postgraduate would meet at least weekly with the PI, with additional dedicated meetings for mentoring and career development.
3. Education / Qualifications: Applicants should be highly motivated, able to work well in a multidisciplinary team, and have strong quantitative skills. A Bachelor’s degree is required at the time of starting the position, preferably in computer science, data scientist, computational biology, biostatistics, or the biological scientists (with quantitative experience).
Interested applicants should send a CV and contact information for 3 references to david.braun at yale.edu<mailto:david.braun at yale.edu>.


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