[bioundgrd] FW: Microbiome Club Seminar: Prof Neel Joshi on 2/24 at 12 PM

[Joshua Stone]

From: Chelsea Catania <cataniac at mit.edu>
Subject: Microbiome Club Seminar: Prof Neel Joshi on 2/24 at 12 PM

MIT Microbiome Club
Seminar Series
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Prof. Neel Joshi
Biologically fabricated materials from engineered microbes
Monday, February 24th t at 12 pm in MIT 56-614<https://whereis.mit.edu/?go=56>
Lunch will be provided. Please RSVP<https://www.eventbrite.com/e/microbiome-club-seminar-prof-neel-joshi-tickets-93830221719>
Abstract: The intersection between synthetic biology and materials science is an underexplored area with great potential to positively affect our daily lives, with applications ranging from manufacturing to medicine. My group is interested in harnessing the biosynthetic potential of microbes, not only as factories for the production of raw materials, but as fabrication plants that can orchestrate the assembly of complex functional materials. We call this approach “biologically fabricated materials”, a process whose goal is to genetically program microbes to assemble materials from biomolecular building blocks without the need for time consuming and expensive purification protocols or specialized equipment. Accordingly, we have developed Biofilm Integrated Nanofiber Display (BIND), which relies on the biologically directed assembly of biofilm matrix proteins of the curli system in E. coli. We demonstrate that bacterial cells can be programmed to synthesize a range of functional materials with straightforward genetic engineering techniques. The resulting materials are highly customizable and easy to fabricate, and we are investigating their use for practical uses ranging from bioremediation to engineered therapeutic probiotics. Another project in the group focuses on interfacing yeast cells with light harvesting nanoparticles to create inorganic-biohybrids with light-driven enhanced metabolic output.

Bio: Neel Joshi is an Associate Professor in the Department of Chemistry and Chemical Biology at Northeastern University. He completed his PhD at UC Berkeley in the lab of Matt Francis and a postdoc at Boston University in the lab of Mark Grinstaff before starting his independent academic career at Harvard University and then moving to Northeastern in January 2020. He is broadly interested in topics related to biologically inspired materials, protein engineering, self-assembly, and biointerfaces. His group works at the intersection of biomaterials science and synthetic biology. Recent projects in the group have focused on repurposing bacterial biofilms and their matrix proteins for biotechnological and biomedical applications.


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The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine. Learn more on our Facebook page. <https://www.facebook.com/MITmicrobiomeclub/> Or follow us on Twitter<https://twitter.com/MITubiomeclub>.

Chelsea Catania, Ph.D.
MIT Microbiome Club Publicity Chair
Postdoctoral Associate
Laboratory for Energy and Microsystems Innovation
Department of Mechanical Engineering
@MITubiomeclub<https://twitter.com/MITubiomeclub>




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