[bioundgrd] FW: Advanced UG Seminar 7.342 Cellular Organelles in Health and Disease

[Joshua Stone]

From: Monther Abu-Remaileh <monther at wi.mit.edu>
7.342  Cellular Organelles in Health and Disease
Instructors:   Nora Kory and Monther Abu-Remaileh (laboratory of David Sabatini)
Spring 2019. Wednesdays 1 pm- 3 pm. (Day and class time are flexible.) Room 68-180.
Course Description
The cell is the basic functional unit of life. Cells perform their diverse functions through a versatile series of biochemical reactions that require different chemical and physical environments. In eukaryotic cells, a complex compartmentalized system consisting of membrane-bound organelles allows these reactions to occur under optimal conditions and prevents accumulation of harmful metabolic intermediates in the wrong places. Additionally, these organelles are sites of signaling and metabolic regulation that enables cells to survive and perform their specialized functions in the body. In this course, we will explore the primary scientific literature to learn about different organelles, including the nucleus, endoplasmic reticulum, mitochondrion, lysosome, peroxisome and the Golgi, in addition to the new emerging field of phase-separated compartments. We will study the biogenesis, biology, and specialized functions of organelles in different organs and tissues, like the function of mitochondria in powering muscle function in some types of muscle but not in others. We will also learn about human diseases that are caused by organelle dysfunction, e.g., storage diseases caused by mutations in lysosomal genes and congenital metabolic disorders in children with mitochondrial gene mutations. We will learn about the biochemical, molecular and cell biological techniques that scientists (including ourselves) use to study cellular organelles. While discussing these multiple aspects of organelle biology, we will learn about scientific reading skills and how to critically think about the scientific literature, identify open questions in the field, and articulate ideas in a research plan. We will visit a research laboratory that studies cellular organelles to see how experiments we discuss in class are performed in the laboratory.

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Monther Abu-Remaileh, PhD
Postdoctoral Researcher, The Sabatini Lab
Whitehead Institute for Biomedical Research/MIT
9 Cambridge Center
Cambridge, MA 02142
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