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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Monther Abu-Remaileh <monther@wi.mit.edu></span><span style="font-size:12.0pt"><o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b>7.342 Cellular Organelles in Health and Disease</b><o:p></o:p></p>
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Instructors: Nora Kory and Monther Abu-Remaileh (laboratory of David Sabatini)<o:p></o:p></p>
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Spring 2019. Wednesdays 1 pm- 3 pm. (Day and class time are flexible.) Room 68-180.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><u><span style="color:black">Course Description</span></u></b>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">The cell is the basic functional unit of life. Cells perform their diverse functions through a versatile series of biochemical reactions that require different chemical and physical
environments. In eukaryotic cells, a complex compartmentalized system consisting of membrane-bound organelles allows these reactions to occur under optimal conditions and prevents accumulation of harmful metabolic intermediates in the wrong places. Additionally,
these organelles are sites of signaling and metabolic regulation that enables cells to survive and perform their specialized functions in the body. In this course, we will explore the primary scientific literature to learn about different organelles, including
the nucleus, endoplasmic reticulum, mitochondrion, lysosome, peroxisome and the Golgi, in addition to the new emerging field of phase-separated compartments. We will study the biogenesis, biology, and specialized functions of organelles in different organs
and tissues, like the function of mitochondria in powering muscle function in some types of muscle but not in others. We will also learn about human diseases that are caused by organelle dysfunction, e.g., storage diseases caused by mutations in lysosomal
genes and congenital metabolic disorders in children with mitochondrial gene mutations. We will learn about the biochemical, molecular and cell biological techniques that scientists (including ourselves) use to study cellular organelles. While discussing these
multiple aspects of organelle biology, we will learn about scientific reading skills and how to critically think about the scientific literature, identify open questions in the field, and articulate ideas in a research plan. We will visit a research laboratory
that studies cellular organelles to see how experiments we discuss in class are performed in the laboratory.<o:p></o:p></p>
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<p class="MsoNormal"><span style="color:#999999">Monther Abu-Remaileh, PhD</span>
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<p class="MsoNormal"><span style="color:#999999">Postdoctoral Researcher, The Sabatini Lab</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:#999999">Whitehead Institute for Biomedical Research/</span><span style="font-size:9.0pt;font-family:"Arial",sans-serif;color:#999999">MIT</span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Arial",sans-serif;color:#999999">9 Cambridge Center<br>
Cambridge, MA 02142</span><o:p></o:p></p>
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