[bioundgrd] FW: Dec 13: Making Pig-to-Human Transplantation a Reality

[Joshua Stone]

From: "Yan, Sherry" <xinrui_yan at radcliffe.harvard.edu>
Subject: Dec 13: Making Pig-to-Human Transplantation a Reality

Hello,
My name is Sherry Yan and I work on the communications team at Harvard’s Radcliffe Institute for Advanced Study (RIAS). I’m passing along information about the Radcliffe Institute’s final fall lecture featuring Luhan Yang, cofounder and CEO of QihanBio. At this event, Yang will discuss her research using CRISPR in order to make whole-heart pig-to-human transplantation possible. I thought this lecture would be relevant to MIT Biology Undergraduate Student Association.

The event is free and open to the public. I would be grateful if you could help amplify this announcement to your community. The formal invitations are below and are designed for convenient e-mail distribution.
Kind Regards,

Sherry Yan
Communications
Radcliffe Institute for Advanced Study | Harvard University
10 Garden Street, Cambridge, MA 02169
www.radcliffe.harvard.edu<https://www.radcliffe.harvard.edu/>
SM: Facebook<https://www.facebook.com/RadcliffeInstitute>, Twitter<https://twitter.com/radinstitute>, and Instagram
<https://www.instagram.com/radcliffe.institute/>
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RADCLIFFE INSTITUTE LECTURE

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Making Pig-to-Human Transplantation a Clinical Reality with CRISPR Genome Editing
Friday, December 13, 4 PM
Radcliffe Institute for Advanced Study, Harvard University
Knafel Center, 10 Garden Street, Cambridge, MA 02138

Lecture by Luhan Yang, cofounder and CEO, QihanBio

Xenotransplantation is a promising strategy to address the shortage of organs for human transplantation. Concerns about pig-to-human immunological compatibility and the risk of cross-species transmission or porcine endogenous retroviruses (PERVs) have impeded the clinical application of this approach.

Using CRIPSR-Cas9, a gene editing technology, eGenesis has been able to inactivate all the PERVs in a porcine primary cell line and generate PERV-inactivated pigs using somatic cell nuclear transfer. Their study highlights the value of PERV inactivation to prevent cross-species viral transmission and demonstrates the successful production of PERV-inactivated animals to address safety concerns in clinical xenotransplantation. Using their genome editing platform, eGenesis is creating pigs with advanced immunological modifications to address immunological and functional compatibility issues.

Please register at www.radcliffe.harvard.edu/event/2019-luhan-yang-lecture<https://www.radcliffe.harvard.edu/event/2019-luhan-yang-lecture>.

This event is free and open to the public. Registration is required. We welcome students (of all levels and institutions) to attend our events, and we encourage you to share this invitation with people you know who may be interested in attending.
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The Radcliffe Institute for Advanced Study at Harvard University is dedicated to creating and sharing transformative ideas across the arts, humanities, sciences, and social sciences. Learn more about the people and programs of the Radcliffe Institute at www.radcliffe.harvard.edu<https://urldefense.proofpoint.com/v2/url?u=http-3A__bit.ly_RadcliffeInstitute&d=CwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=mkqahl5yyMRAdUQInWqa6IfGx5BdK6IW-Vd0omuWxJaN-MTRKmfiQmmyFl_DE6Oe&m=QJgaDgdXPRG1z0PAgIA3UCx84tC9HHQV8iuE0zYznrI&s=2mWM8q8PvrQ5MvqOYtMIN8iyxdIRNq3Rkvn5YW14ecs&e=>.
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