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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">"Yan, Sherry" <xinrui_yan@radcliffe.harvard.edu><br>
<b>Subject: </b>Dec 13: Making Pig-to-Human Transplantation a Reality<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">Hello,</span><span style="font-size:12.0pt;color:black">
</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">My name is Sherry Yan and I work on the communications team at Harvard’s Radcliffe Institute for Advanced Study (RIAS). I’m passing along information about the Radcliffe Institute’s final fall
lecture featuring Luhan Yang, cofounder and CEO of QihanBio. At this event, Yang will discuss her research using CRISPR in order to make whole-heart pig-to-human transplantation possible</span><span style="font-size:10.5pt;color:black">.
</span><span style="font-size:10.0pt;color:black">I thought this lecture would be relevant to MIT Biology Undergraduate Student Association.
</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">The event is free and open to the public. I would be grateful if you could help amplify this announcement to your community. The formal invitations are below and are designed for convenient e-mail
distribution.</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">Kind Regards,</span><span style="font-size:12.0pt;color:black">
</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
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<p><span style="font-size:10.0pt;color:black">Sherry Yan</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">Communications</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">Radcliffe Institute for Advanced Study | Harvard University</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">10 Garden Street, Cambridge, MA 02169</span><span style="font-size:12.0pt;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><a href="https://www.radcliffe.harvard.edu/" target="_blank"><span style="font-size:10.0pt">www.radcliffe.harvard.edu</span></a><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">SM: </span><span style="font-size:12.0pt;color:black"><a href="https://www.facebook.com/RadcliffeInstitute" target="_blank" title="https://www.facebook.com/RadcliffeInstitute"><span style="font-size:10.0pt">Facebook</span></a></span><span style="font-size:10.0pt;color:black">,
</span><span style="font-size:12.0pt;color:black"><a href="https://twitter.com/radinstitute" target="_blank" title="https://twitter.com/radinstitute"><span style="font-size:10.0pt">Twitter</span></a></span><span style="font-size:10.0pt;color:black">, and <a href="https://www.instagram.com/radcliffe.institute/" target="_blank" title="https://www.instagram.com/radcliffe.institute/">Instagram<br>
</a></span><span style="font-size:12.0pt"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><img border="0" width="472" height="110" style="width:4.9166in;height:1.1458in" id="Picture_x0020_2" src="cid:image001.png@01D5AAAA.A9C5EA60"></span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:12.0pt;color:black"> </span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><b><span style="font-size:12.0pt;color:black">RADCLIFFE INSTITUTE LECTURE</span></b><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:12.0pt;color:black"> </span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:12.0pt;color:black"><img border="0" width="225" height="225" style="width:2.3437in;height:2.3437in" id="Picture_x0020_1" src="cid:image002.png@01D5AAAA.A9C5EA60"></span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:12.0pt;color:black"> </span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><b><span style="font-size:14.0pt;color:black">Making Pig-to-Human Transplantation a Clinical Reality with CRISPR Genome Editing</span></b><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black">Friday, December 13, 4 PM</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black">Radcliffe Institute for Advanced Study, Harvard University</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black">Knafel Center,<span class="apple-converted-space"> </span>10 Garden Street, Cambridge, MA 02138</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black"><br>
Lecture by <b>Luhan Yang</b>, cofounder and </span><span style="font-size:10.5pt">CEO<span style="color:black">,
</span>QihanBio</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:12.0pt;color:black"> </span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black">Xenotransplantation is a promising strategy to address the shortage of organs for human transplantation. Concerns about pig-to-human immunological
compatibility and the risk of cross-species transmission or porcine endogenous retroviruses (PERVs) have impeded the clinical application of this approach.</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black"> </span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black">Using CRIPSR-Cas9, a gene editing technology, eGenesis has been able to inactivate all the PERVs in a porcine primary cell line and generate PERV-inactivated
pigs using somatic cell nuclear transfer. Their study highlights the value of PERV inactivation to prevent cross-species viral transmission and demonstrates the successful production of PERV-inactivated animals to address safety concerns in clinical xenotransplantation.
Using their genome editing platform, eGenesis is creating pigs with advanced immunological modifications to address immunological and functional compatibility issues.</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black"> </span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:10.5pt;color:black">Please register at<span class="apple-converted-space">
<a href="https://www.radcliffe.harvard.edu/event/2019-luhan-yang-lecture">www.radcliffe.harvard.edu/event/2019-luhan-yang-lecture</a>.</span></span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;color:black"> </span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><b><i><span style="font-size:10.5pt;color:black">This event is free and open to the public. Registration is required. We welcome students (of all levels and institutions) to attend our
events, and we encourage you to share this invitation with people you know who may be interested in attending.</span></i></b><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span style="font-size:12.0pt;color:black"> </span><span style="font-size:10.5pt;color:#7F7F7F">------------------------------------------------------------------------------------------</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-caps: normal;word-spacing:0px"><span class="apple-style-span"><span style="font-size:10.0pt;color:gray">The<b> Radcliffe Institute for Advanced Study</b> at Harvard University is dedicated to creating and sharing transformative
ideas across the arts, humanities, sciences, and social sciences. Learn more about the people and programs of the Radcliffe Institute at </span></span><span class="apple-style-span"><span style="font-size:10.0pt;color:black"><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__bit.ly_RadcliffeInstitute&d=CwMFAw&c=WO-RGvefibhHBZq3fL85hQ&r=mkqahl5yyMRAdUQInWqa6IfGx5BdK6IW-Vd0omuWxJaN-MTRKmfiQmmyFl_DE6Oe&m=QJgaDgdXPRG1z0PAgIA3UCx84tC9HHQV8iuE0zYznrI&s=2mWM8q8PvrQ5MvqOYtMIN8iyxdIRNq3Rkvn5YW14ecs&e="><span style="color:gray">www.radcliffe.harvard.edu</span></a></span></span><span class="apple-style-span"><span style="font-size:10.0pt;color:gray">.</span></span><span style="font-size:12.0pt"><o:p></o:p></span></p>
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