[bioundgrd] Spring Issue of Biolog: the MIT Department of Biology Newsletter

Fri Mar 2 14:44:54 EST 2018

View this email in a web page <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe9Yb0lT6ldFBVdgiChJXsvzHtzGc80CH03UKkhdQu8kLYvRn4XfIbPMueduUVXdvYUt27pbo82xWUHth-2BlDvYaQ-3D-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6dAu7Q0Y-2FDfgRVfRKFBXDF-2FcBsD03RE1zjkdyC-2FLlDBJ3ibbBBflv5TNh8IgesB-2FyuYwSntMJ8WAS-2Fbfp6qMEGgXww958actVpEfHVcc7dqjUSYi2kp6nVfbaqa1wAjfOl6YhHOiUSfJI2r6WzgTeDQNN5WRHD-2BcSakY3JZSDWKg-3D-3D>

Dear Friends and Alumni of MIT Biology, 

Spring is in the air with its lengthening days and sense of new beginnings: spring training and excitement for the new season; first year undergraduates declaring their majors; and graduate school open houses. And just in time for these students to be deciding what departments to call their homes, we have launched our new website, which aims to answer the question “Why MIT Biology?” while simultaneously offering plenty of practical information for our internal biology community. Please take a look <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOePCBrBT-2FYVsa11p0fB9wfJl8FnQplWq-2FtfpdEcnzOSbA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5LRKNwqCkyxNgPr9NX7F6wujLHUaYRi5X7oneSli7tJcwWS4X57YPnPCo-2FLFGF3d8LFy6JmpMNJnYqrlHtyGA-2B5hg-2FLZewxvz74mHTZPzmUvUq4430sdww5CraKztczVgvgEe5V5irmS-2Fv3cATyNrW86Hoi30s3-2FUBI3GedMBJMg-3D-3D> and let us know what you think! In this spring newsletter, we also share faculty, administrative, and alumni news; recent happenings around the department; and highlights of some of the research we have published in the last few months. We hope that you enjoy the newsletter and that it stimulates your interest. As always, we welcome your feedback and questions at bioheadline at mit.edu <mailto:bioheadline at mit.edu>. 

Sincerely, 

Alan

ALAN D. GROSSMAN
PRAECIS PROFESSOR OF BIOLOGY; DEPARTMENT HEAD
FACULTY NEWS
The School of Science appointed <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOefHj7jfr1AGEAfEXVJpGybCPHnYy6w9KnPIE4b77xwqo-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE41IbN-2Bs3piO6PWunvCXPbhaEeN-2BvR2FIFqoq4UTq3tate4tcM2W7qnpaS3DZiTe-2FepK06qlyJnE1V05ELJCVlmM7RJx-2FZ8vDWmer4jERxK9NHr8321XYgdiR8Ze9Wu1jtBa12ONSAVWOy3rbh2QT6KUulqlGhtudoUEirOPJr-2B-2Bw-3D-3D> Steve Bell to the Uncas (1923) and Helen Whitaker Professor, Stefani Spranger to the Howard S. (1953) and Linda B. Stern Career Development Assistant Professor, and promoted Iain Cheeseman to Full Professor.

ADMINISTRATIVE NEWS
Ed Brignole, previously a research scientist with Cathy Drennan, began as the Assistant Director of the Cryogenic Electron Microscopy Facility in December. His primary role includes overseeing the facility once the MIT.nano <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeefd0gqAwvXy4D7jrHH1r6OVewro4EFNxC4uVATZURTE-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4QmE7QUYe1ZI3QwdOL6YH71-2FpZX5KSlGT3HO1FyAOAmNc-2FMK1XALlIE8Iyu-2BgY1AVLQW-2BKMMG34FrB7ftWz-2F80w4uDGjdOXcFK-2Ba2iZoylq3ScW59tdf0uLdCKgGqPgjY484JOK8kUdEaWE5vRbwUgMTVqKfy-2BBxTxxN96shPzQA-3D-3D> building opens in mid-2018.

ALUMNI NEWS
Ben Barres SB ’76 passed away <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeq-2BbdA9v4VDspxqsZIIsGSBBlu0ie-2FsWNVZkwpsU9iEU-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE64-2BEwlwM9yVqrMx60Q-2Bh76VDrAcy8jQf726i3-2BqVTwrx06WktxOO7Qszef8NKTmKhaGHSFmBBii5VFHYzutqDe44mqaKSGz1uyMjsAx1Yl-2BVLOGIoxcQuPhciMKWxUFCJGAP4eZBNZT68fWp0-2BQNespvsAhm054paThSp2KdgpcA-3D-3D> on Dec. 27, 20 months after being diagnosed with pancreatic cancer. He revolutionized the study of neuroscience by identifying the crucial role glial cells play in brain wiring and function, and in doing so seeded an entire field. He was also the first openly transgender researcher in the U.S. National Academy of Sciences and a champion both for women in science and the LGBTQ community.

EDUCATION AND OUTREACH 
Biology’s MITx Curriculum Development Specialist, Mary Ellen Wiltrout PhD ’09, was included on the Reimagine Education shortlist for Hybrid Learning for the project, "Teaching MIT Students to Think Like Cell Biologists: A Visual Approach," which she developed with Sera Thornton PhD '14, Frank Solomon, and Adam Martin for the 7.06 Cell Biology course. The project was one of 1,041 submissions across 17 categories, of which just 140 were shortlisted to give a talk at the conference. You can view a brief video of the project here <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe9LIw7QZkML74Nr4TX8BpvU1iM23jfcDNSyYjp-2FGwICI-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5husbb6LITM2cwwoKFPdshGU5bYg1Flgro47NV4kibzGSbX81EDZW5RAK4xYcculSwT8elg5t6QzMPxrqT2NrJoI9uGy-2FK4HN7vZJZ4onxFNcLPFkH7rh9vZ-2FgWauJJcqnBkoRMWmrQxVpWQvHG1LusDB5737ibIGWxyLQjb3cmw-3D-3D>. 

 AROUND THE DEPARTMENT
 <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOePCBrBT-2FYVsa11p0fB9wfJl8FnQplWq-2FtfpdEcnzOSbA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6XKPsEEjreZ4QM70llN4de8ZL-2F4vJp4hoBpLFYsDldcux15baetJP-2Fckrw9NF9vO7LZAI2ubRRSuMNFQEHooGKiv1MOPkmdXsaDSW9MC77fKI0IGlUeAwndj03mPjtAnc4a2RWSAP87SWvN60ZmAp5KoJAZWqadpxJ1by1nf5iSw-3D-3D>
Have you seen the new face of MIT Biology? <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOePCBrBT-2FYVsa11p0fB9wfJl8FnQplWq-2FtfpdEcnzOSbA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7f89zj-2FXawcWPytIedFhOvUnFy9asZQ6Rb7craAZxNDlS-2BWOi-2B1OmoNawF-2Baqmrf6aJSYP9Ejm58-2FNo5M-2Fy8PIuy1ueiL-2FLaR7QGka7s1OukefFjGNWaU-2BJXFLheJfvPN1TPZ0VJmhPnT275EcN92b89sQgzsFjgoBX9vj-2BeQtsQ-3D-3D>
We are pleased to announce the launch of our redesigned, reimagined, and revamped website. 

 <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe-2FGhF-2FIzoUNYBnF0NMl4OqoPicE67xbKbDZv0fxAwo0E-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7EH3-2BjGOqu9uahASXEkjm4TTCYR7uZJpKCx2EmpmWv-2BZj5T74H9F6Lkr07j9EGsCNFqxgJEVsttjbPkJAeJy-2F3at9D-2BJupKCmEYHCgqlW2b2XGVzaNHJwmv13nHOJ-2F51aNXUuApmkSOyfT0AfcT-2BkYU-2B6vReml9JdiYnmFcUKjdQ-3D-3D>
Fine-tuning cancer medicine <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe-2FGhF-2FIzoUNYBnF0NMl4OqoPicE67xbKbDZv0fxAwo0E-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4RP1OGg4VIi9YTzttA6fC5hI7CLwRSfQwxtXQnGWxwDNuEAXEyDEgonYRe5y7LxNnjt-2FeU6lPZ8T1dRNlaeXoFqghXMgOiRpJPj8-2B0eIs6k5ORYMvXOV5F76024c7ZqnVCpfDOeOBJNXPHSnhDautP5ChkeLlkbVq-2FEwIs1w7WjA-3D-3D>
The Koch Institute for Integrative Cancer Research recently announced the launch of its new Center for Precision Cancer Medicine (CPCM). The center brings together leading Institute faculty members to focus on key research themes to accelerate the clinical translation of novel cancer discoveries, treatments, and technologies.

 <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeQeQ1y3lmKLoX-2BrDGVogvzM52J-2FAUVrfehHzigZ2KZpI-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7XeoVpt5wruFEys7-2BvabC2C5kT9P1N6f5qwTzMXEHE7ws-2F1KKjC2SVPjsMQcD71zPJgnb1B0E0VrPw1vKw6TIQNNrwbGkWsyfWAi3KsigS8aX3hVSWN3qSazyFER4Mf1GzaScFiwNjTuUBes5KyENLygNBNzvL-2B4jIST5vtEV2ww-3D-3D>
Reading and writing DNA <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeQeQ1y3lmKLoX-2BrDGVogvzM52J-2FAUVrfehHzigZ2KZpI-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7Ct-2BbiiYJ5LtCPsLm6S6YBn5BbV1k1Pu-2BN3qcsDIux1XkEOwQ4R4TrCZEJoEYi3hR-2B67o14JPi5rFa5nqUJ41aaA00teJJWt8InyrCkFSRZU5o18fpM8dnL7Q4zEUlvlHpOvNVp-2Fbr-2FmtX3EpVZ1atlFhchCPElVY7a6Sbvf19zw-3D-3D>
We invited pioneer of synthetic biology, George Church, to kick off our IAP seminar series, “Biology at Transformative Frontiers,” and speak about his work reading, writing, and editing the genome. The future, as he sees it, sounds a bit like something out of a sci-fi novel.

 <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeiBcff-2FjEVVJnL-2BKJlxg-2BqhPorumPCmSRUDsvHZxPCsA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7jOYU18v-2BM9vnqGAVP0VUNtLhyM2SpyVJtJH88W1YpyA3W9TPLZ0dU-2B-2FKj2MVXRo1m9fQcGpK7Rkur81eOoAQSA7NrCdCw0iHd9-2FTgvNoSj-2B0W-2BEPc0X4k50iaAfluhID1h9JVFfNu-2B3qvoQxUYPTerKS5R-2B6vyV1JqHM7A4d1pQ-3D-3D>
Face Time <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeiBcff-2FjEVVJnL-2BKJlxg-2BqhPorumPCmSRUDsvHZxPCsA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4f5EYewTZdd-2BEP3Tv85f-2FXTgkjGRE5lWFXFsCAo8PvuEVSb6tuvWahvIrdHgGlHraylgnfA4xHKZ-2FuKR-2Fy6ogZh7DcFJ34D5QkO792gjjRXIFWXG5LY4pFWSOP66eJyPxuwRSZJ-2BtmG5e3IYv0cTkfIWqWgJa7W-2BgJ8q9k1QVDYQ-3D-3D>
Newly minted PhD, Justin Chen, reflects on his experience in Hazel Sive’s lab studying developmental biology — investigating the complex beauty of how a face emerges from embryonic tissue. In his own words, "How nature makes something from almost nothing."

In early February, the department hosted its annual Undergraduate Research Symposium, featuring nine students doing biology-related UROPs around the Institute. Later that month, we welcomed prospective graduate students to campus for two open houses involving faculty talks, student panels, interviews, and other events. 

 <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeeetjRvohcxwq2WWgMBc0j3sfacJlRzbTmH6rDfljlEo-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6geOXG1fRKWRoQsQUL56OSgtj6vkfeKJBMQR1yD6ZbBffL4O6nEhj7NIOKcZQlY6dvnywSszjKpxZIylhYD-2F9TrGCEfIz3DC3jLFxnyUVPv0FR-2B6NgEtnVU-2FcoiB4IDoz93FscNynPIPSdyQEU7kuC1q-2FzGG-2BiQEvacL5VgmI-2FRw-3D-3D>
Postdoctoral fellows Lydia Herzel and Peter Sudmant received <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeeetjRvohcxwq2WWgMBc0j3sfacJlRzbTmH6rDfljlEo-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5L0HJmGOcyCDLQr7gxx6nTnXamjNKfCioQ3G7wM-2FirspVSSp3OasoEQG9CSFx02mtYWiHW4JZF9uvUIJvpER6gcPPhy9AWWGCZI15D-2BWEjCLTFC8X5AlxJvwHa7giPkJN6EPTugN6mppELbq09SwZzpFXcCzPhMkvmZlD6jzJ22w-3D-3D> Infinite Kilometer Awards for their mentorship, participation in educational programs, and contributions to the MIT Postdoctoral Association and greater MIT community.
RESEARCH HIGHLIGHTS

What follows is a sampling of recently published research across the department — for a more complete list of publications, click here <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOerPNi0ZiRCh0IX085MYFUwdbC1nRk1YehGmzmCBY-2BlT4-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6orxhb3fmwEBmoEi2xJUuQ3S5TnymBc1MSM-2B8oGnD0ZiD3s0s8CRlcDDZiWBWmJ3VGhrzJfbifqLY4UhThKdhKjlychba-2FFBqpmh71ItHA3EpeTiqEJBtB8oEVCdFBfoshzBbRo6m7AAPxJ-2BxE8qCAm9BWbkjpzQKxC3kNxssSpQ-3D-3D>. If there is a paper you would like to see highlighted in the next issue of the newsletter, please email mcelvery at mit.edu <mailto:mcelvery at mit.edu> or vivians at mit.edu <mailto:vivians at mit.edu>.

Graduate student David Phizicky and Professor Steve Bell investigated <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeqazAihGBOOjPbTU1GY6u92SSSNBfUal6t3lva44eu1M-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4W9ZEV2G31IxnBImmtyl4M29Ef-2BTS9UgkwDgEE3t4tjMqwgSo9e6x-2BlYIqOtUvE8eMaLt7EpixXniBUld8-2BgI-2F1Ui0EbPmHb6VBExnYureEFXI7PBBcjRL-2FFugFhoeLhnGyxd8-2BZc5LJ-2Fu2dmdgUBRUgDYH1BZkWVll8Jyy8G07A-3D-3D> how DNA replication is inhibited between meiotic divisions, revealing that multiple kinases inhibit both helicase loading and activation between divisions to ensure reductive cell division.

Professor Eliezer Calo explored <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeJSkquWTvaQuvzYGAX-2BJA9GC9zi0Mb7GSQcrbQ7dRAlE-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7tpjwR-2Badex0sr9Yj38RJkCS9dvTY-2Bkrqv0-2FSe8TvZ0wBYT4Zx8sqHt4vyRJ7EgXHegoL6z9JE8V5jndl4CttfAnYbu9VB-2BVmVJSuZtWS3tZ82jJNatix9rkEtRnc4tDCvUCND05OrGqCQ8r-2BdcqEtt-2Fn0vZBwq8cQSE2HKvE4ug-3D-3D> the molecular functions of DDX21, a DEAD-box RNA helicase, uncovering a previously unappreciated mechanism linking nucleolar dysfunction, ribosomal DNA damage, and craniofacial malformations. 

Postdoctoral researcher Raheleh Rezaei Araghi and Professor Amy Keating modified <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeqe1gSTOpgLyxZ1idkyqEYVwCMR9jhHnNztO0TaSI1nE-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5YgJDhgeqgYXQrn3OUysnD-2B6okyKXA6uBBpNOi5gNdTYPac88TYl-2BYYAGRSCO9dGNd9-2FL5-2BgTTfJVLMAY2vt8KVeYDmdrlOKr8UrEF-2FnBxDxxd2Y-2FAFDIblJkGFS1Yea1ka0P0Zv9rxNMlpkKvMfNSiCc7gj62D8ruxMC7FHSrkQ-3D-3D> a key cancer survival protein called Mcl-1 to selectively kill cancer cells, and demonstrated how systematic optimization can transform a lead peptide into a drug prototype suitable for diagnostic and therapeutic development.

Research assistant Saima Sidik, postdoctoral researcher Diego Huet, and Professor Sebastian Lourido employed <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOefHAYBLclXRKWPCVhioYEnUV32IwMt-2B3uo2VtG6P7u7E-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6Nmm8THtgKRFcgZ-2B5tTGlJehES8qkHqqruhc9ZTcc2RcfhKtAjRA-2BMqFnoxiUOG6jp1DZeyyY9JhBSO1RcwHQTiYLtzV8mBqzXujd9JSoVJGafTkhv1seWEGr4U4wdfpZpS-2F4pz4jvSA1d4xtvJSiW3FxuZxL326j5ELbP8WiLvQ-3D-3D>CRISPR-Cas9 to disrupt all nuclear protein–coding genes in T. gondii using a pooled format, presenting a workflow that permits a genome-wide screen and analysis in just three weeks.

Proceedings of the National Academy of Sciences published a profile <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeEUBzBPCo4wN8g0Xq2neHBh6nwQuqckxd4cnYQB7eTew-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5mPTvBWBx4E9fIdn3WeT0OOJ4XN2mipXQ1EqlQcfbo-2BXvUiK5FKozZ1G5buzEJTi4-2FCOHExLtfZg9Xzn3joESBeTPDZ0Q7zJDbD16mePTDbUYY8-2BYYB-2FdDN0s97-2F4PULatykoZ-2FAQ0LNHMR2-2BmefaqqnUMmu4bshyat-2BDox8YpnQ-3D-3D> of David Sabatini, chronicling his research developments related to the mTOR pathway.

Graduate student Grace Chen and Professors Hazel Sive and David Bartel determined <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeNtLI7fdQLAFSO3QR9rkQfjjgLcZ3Icz79iPyrbENZcY-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4bc7jyMTIvGaJOD2o8mdLoX12Jt64OKFB0WEWK-2FILv8Tz1nJw0YwYm8EZH3kHBEcKu9g35Pil46JmVNGbxb2ZIV8CrEhXQjLa2pZlYOja4sRTuW6RB-2Fu5IrzEm4k0ua2bDdu8ervg6Jj6n6vZVd9JTouGDCFO4gmqfMokkFw5pFw-3D-3D> that RNAi is less effective in zebrafish partly because Argonaute2-catalyzed mRNA slicing is impaired — providing a strategy for restoring RNAi using a microRNA generated by a cleavage reaction analogous to slicing.

New Assistant Director of the Cryogenic Electron Microscopy (cryo-EM) Facility Ed Brignole, Professor Emerita JoAnne Stubbe, and Professor Cathy Drennan presented <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeMuk5cfd7Y8noMGqXY1ggdbtiYjFZ7Mu6YWw9E9drNkQ-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5B4aFMf01zEXFKcZNsJNrVMSySwhTYDgPGOsBC13WDlZZnL0EAbrbUvqX5hzEy1B0A6aw5VwDgdFuk5Id3iDbhEAAlZ-2FRhNsQPMu6EqIc0bKCYGk1dGJ7kI-2FHrq7xQPE-2ByXMpyekbxOE0lLUU3PgkBmCltPZaf7pr4c9vVzCCUgA-3D-3D> a 3.3-Å resolution structure using cryo-EM of a dATP-inhibited state human ribonucleotide reductase (RNR), providing a model for RNR inhibition with ramifications for new anticancer and antibacterial drugs.

Former research scientist Akiko Wagatsuma and Professor Susumu Tonegawa demonstrated  <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeN06iGf-2BMwLLeA6iKXduRJr7t5Yo7mymrg-2BHlQCbJVxA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4TKcz-2FYNYLsN8VgoOYRTGAyXAP-2FVhs5iSFhuueA7t3aXRk86pAOAoOHCJExxpFZ8pZp-2BhzhJ2QZNs0Pz9P6ea4qBHdcjgd-2B9iGx1BKXA-2BdJ7S-2BcwY3A78-2BXFI6zL9eLVUAfFv-2B-2F-2FTnmQEgtEfcXFERtPTCripLLwYNbNhCfHoN9g-3D-3D>that locus coeruleus neuromodulation, especially to the CA3 subregion, plays a crucial role in memory formation of a new context.

Current postdoctoral researcher Shawn Liu, former postdoc Hao Wu, Professor Richard Young, and Professor Rudolf Jaenisch developed <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe0XORYLvwwJv6yhoEpAm1vJhnW-2B3d7z-2FS5jIcFhUnu-2Bk-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7mfG2UewbcTO9hu2WAiEzrFg5ucbrDku1OaBml-2Bcg7meaJcMOVKhiXlgfkXs4kDoB090LyZjbWJh7fX-2FqFPDtuVfsff5Eem5waSdkggcZ7d81ASckwsAemEY2IO7wkYudyp15xzFbf684dUlR7LiV08GHqlnAqH1zfuXGZ3nksbA-3D-3D> DNA methylation editing tools to reverse the hypermethylation of the FMR1 gene, reactivating it and rescuing neurons affected by fragile X syndrome.

Visiting scientist Nick Kwiatkowski, postdoctoral researcher Brian Abraham, and Professor Richard Youngdetermined <http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeyxpDvCYCdVE1T1C7djnpoAIWyyHBhqMA2uWcG5RxW-2Bg-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4Sk-2BPYwa0HkFZs7qMem9vD2f6jUX4hjCTIwaS9sM1-2BqRSHHdMowrklUsCqSrajKOt27GCHt-2BShh22nd-2BkY8EPg8-2F51Hqlz1HDj2wBoYomqtrbbJ3bnFZTethcCjq09WPrbXnzd4kIbeio9J-2FXN748N9FJ2Bp77OKhYgouivVJqmA-3D-3D> that Ewing sarcoma cells are highly sensitive to CDK7/12/13 inhibitors, and the combination of these molecules with PARP inhibitors shows prominent synergy in multiple models of the disease.
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