<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><br class=""><div><div class="">
<meta http-equiv="Content-Type" content="text/html; charset=utf-8" class=""><div style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><br class=""><div class=""><br class=""><div class=""><div style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: center; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px;" class=""><div style="padding: 20px;" class=""><div id="divHostedEmailLink" style="margin-bottom: 15px; text-align: center; font-family: Arial, Helvetica; font-size: 11px;" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe9Yb0lT6ldFBVdgiChJXsvzHtzGc80CH03UKkhdQu8kLYvRn4XfIbPMueduUVXdvYUt27pbo82xWUHth-2BlDvYaQ-3D-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6dAu7Q0Y-2FDfgRVfRKFBXDF-2FcBsD03RE1zjkdyC-2FLlDBJ3ibbBBflv5TNh8IgesB-2FyuYwSntMJ8WAS-2Fbfp6qMEGgXww958actVpEfHVcc7dqjUSYi2kp6nVfbaqa1wAjfOl6YhHOiUSfJI2r6WzgTeDQNN5WRHD-2BcSakY3JZSDWKg-3D-3D" style="color: rgb(2, 174, 238);" class="">View this email in a web page</a></div><table border="0" cellpadding="0" cellspacing="0" style="margin-left: auto; margin-right: auto; width: 635px; text-align: left;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><div style="clear: both;" class=""><div class=""><p class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/biology-logo_small.jpg" alt="" width="317" height="83" class=""><br class=""></p><table width="635px" class=""><tbody class=""><tr class=""><td style="border: 0px; padding: 0px 0px 20px; color: rgb(19, 19, 19); display: block; line-height: 23px; font-family: arial, helvetica, sans-serif;" class=""><p class=""><span style="font-size: 16px;" class="">Dear Friends and Alumni of MIT Biology, </span></p><p class="MsoNormal"><span style="font-size: 16px;" class="">Spring is in the air with its lengthening days and sense of new beginnings: spring training and excitement for the new season; first year undergraduates declaring their majors; and graduate school open houses. And just in time for these students to be deciding what departments to call their homes, we have launched our new website, which aims to answer the question “Why MIT Biology?” while simultaneously offering plenty of practical information for our internal biology community. Please take a<span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOePCBrBT-2FYVsa11p0fB9wfJl8FnQplWq-2FtfpdEcnzOSbA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5LRKNwqCkyxNgPr9NX7F6wujLHUaYRi5X7oneSli7tJcwWS4X57YPnPCo-2FLFGF3d8LFy6JmpMNJnYqrlHtyGA-2B5hg-2FLZewxvz74mHTZPzmUvUq4430sdww5CraKztczVgvgEe5V5irmS-2Fv3cATyNrW86Hoi30s3-2FUBI3GedMBJMg-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">look</a><span class="Apple-converted-space"> </span>and let us know what you think! In this spring newsletter, we also share faculty, administrative, and alumni news; recent happenings around the department; and highlights of some of the research we have published in the last few months. We hope that you enjoy the newsletter and that it stimulates your interest. As always, we welcome your feedback and questions at<span class="Apple-converted-space"> </span><a href="mailto:bioheadline@mit.edu" style="color: rgb(128, 0, 0);" class="">bioheadline@mit.edu</a>. <br class=""><br class="">Sincerely, <br class=""><br class="">Alan</span><br class=""></p></td></tr></tbody></table><table class="" style="width: 635px;"><tbody class=""><tr class=""><td class="" style="border: 0px; padding: 0px 10px 10px 0px; text-align: left; vertical-align: top;"><img src="http://mit.imodules.com/s/1314/images/gid13/editor/departments/biology/alan_grossman.jpg" alt="" width="62" height="78" class=""><br class=""></td><td class=""><strong="" style="border: 0px; padding: 0px 0px 10px; font-size: 18px; color: rgb(34, 34, 34); text-transform: uppercase; display: block; line-height: 23px; font-family: arial, helvetica, sans-serif;" class="">ALAN D. GROSSMAN<br class="">PRAECIS PROFESSOR OF BIOLOGY; DEPARTMENT HEAD<br class=""></strong=""></td></tr></tbody></table><table width="635px" style="width: 635px; height: 21px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><hr class=""></td></tr></tbody></table><table style="width: 652px; height: 39px;" class=""><tbody class=""></tbody></table><table style="width: 635px; height: 336px; top: 708px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><p class=""><span style="font-family: arial, helvetica, sans-serif; font-size: 18px;" class=""><strong class="">FACULTY NEWS<br class=""></strong></span><span style="font-size: 16px;" class=""><span style="font-family: arial, helvetica, sans-serif;" class="">The School of Science<span class="Apple-converted-space"> </span></span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOefHj7jfr1AGEAfEXVJpGybCPHnYy6w9KnPIE4b77xwqo-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE41IbN-2Bs3piO6PWunvCXPbhaEeN-2BvR2FIFqoq4UTq3tate4tcM2W7qnpaS3DZiTe-2FepK06qlyJnE1V05ELJCVlmM7RJx-2FZ8vDWmer4jERxK9NHr8321XYgdiR8Ze9Wu1jtBa12ONSAVWOy3rbh2QT6KUulqlGhtudoUEirOPJr-2B-2Bw-3D-3D" target="_blank" style="color: rgb(128, 0, 0); font-family: arial, helvetica, sans-serif;" class="">appointed</a><span style="font-family: arial, helvetica, sans-serif;" class=""><span class="Apple-converted-space"> </span></span><strong style="font-family: arial, helvetica, sans-serif;" class="">Steve Bell</strong><span style="font-family: arial, helvetica, sans-serif;" class=""><span class="Apple-converted-space"> </span>to the Uncas (1923) and Helen Whitaker Professor, </span><strong style="font-family: arial, helvetica, sans-serif;" class="">Stefani Spranger</strong><span style="font-family: arial, helvetica, sans-serif;" class=""><span class="Apple-converted-space"> </span>to the Howard S. (1953) and Linda B. Stern Career Development Assistant Professor, and promoted<span class="Apple-converted-space"> </span><strong class="">Iain Cheeseman</strong><span class="Apple-converted-space"> </span>to Full Professor.</span></span></p><p class=""><span style="font-family: arial, helvetica, sans-serif;" class=""><strong class=""><span style="font-size: 18px;" class="">ADMINISTRATIVE NEWS</span></strong><br class=""><span style="font-size: 16px;" class=""><strong class="">Ed Brignole</strong>, previously a research scientist with Cathy Drennan, began as the Assistant Director of the Cryogenic Electron Microscopy Facility in December. His primary role includes overseeing the facility once the<span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeefd0gqAwvXy4D7jrHH1r6OVewro4EFNxC4uVATZURTE-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4QmE7QUYe1ZI3QwdOL6YH71-2FpZX5KSlGT3HO1FyAOAmNc-2FMK1XALlIE8Iyu-2BgY1AVLQW-2BKMMG34FrB7ftWz-2F80w4uDGjdOXcFK-2Ba2iZoylq3ScW59tdf0uLdCKgGqPgjY484JOK8kUdEaWE5vRbwUgMTVqKfy-2BBxTxxN96shPzQA-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">MIT.nano</a><span class="Apple-converted-space"> </span>building opens in mid-2018.</span><br class=""><br class=""><span style="font-size: 18px;" class=""><strong class="">ALUMNI NEWS</strong></span><br class=""><span style="font-size: 16px;" class=""><strong class="">Ben Barres</strong><span class="Apple-converted-space"> </span>SB ’76<span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeq-2BbdA9v4VDspxqsZIIsGSBBlu0ie-2FsWNVZkwpsU9iEU-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE64-2BEwlwM9yVqrMx60Q-2Bh76VDrAcy8jQf726i3-2BqVTwrx06WktxOO7Qszef8NKTmKhaGHSFmBBii5VFHYzutqDe44mqaKSGz1uyMjsAx1Yl-2BVLOGIoxcQuPhciMKWxUFCJGAP4eZBNZT68fWp0-2BQNespvsAhm054paThSp2KdgpcA-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">passed away</a><span class="Apple-converted-space"> </span>on Dec. 27, 20 months after being diagnosed with pancreatic cancer. He revolutionized the study of neuroscience by identifying the crucial role glial cells play in brain wiring and function, and in doing so seeded an entire field. He was also the first openly transgender researcher in the U.S. National Academy of Sciences and a champion both for women in science and the LGBTQ community.</span></span></p></td></tr></tbody></table><table width="635px" style="width: 635px; height: 21px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><hr class=""></td></tr></tbody></table><table style="width: 631px; height: 33px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><span style="font-family: arial, helvetica, sans-serif;" class=""><span style="font-size: 18px;" class=""><strong class="">EDUCATION AND OUTREACH </strong></span><br class=""></span><span style="font-family: arial, helvetica, sans-serif; font-size: 16px;" class="">Biology’s MITx Curriculum Development Specialist,<span class="Apple-converted-space"> </span><strong class="">Mary Ellen Wiltrout</strong><span class="Apple-converted-space"> </span>PhD ’09, was included on the Reimagine Education shortlist for Hybrid Learning for the project, "Teaching MIT Students to Think Like Cell Biologists: A Visual Approach," which she developed with<span class="Apple-converted-space"> </span><strong class="">Sera Thornton</strong> PhD '14,<span class="Apple-converted-space"> </span><strong class="">Frank Solomon</strong>, and<span class="Apple-converted-space"> </span><strong class="">Adam Martin</strong><span class="Apple-converted-space"> </span>for the 7.06 Cell Biology course. The project was one of 1,041 submissions across 17 categories, of which just 140 were shortlisted to give a talk at the conference. You can view a brief video of the project<span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe9LIw7QZkML74Nr4TX8BpvU1iM23jfcDNSyYjp-2FGwICI-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5husbb6LITM2cwwoKFPdshGU5bYg1Flgro47NV4kibzGSbX81EDZW5RAK4xYcculSwT8elg5t6QzMPxrqT2NrJoI9uGy-2FK4HN7vZJZ4onxFNcLPFkH7rh9vZ-2FgWauJJcqnBkoRMWmrQxVpWQvHG1LusDB5737ibIGWxyLQjb3cmw-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">here</a>. <br class=""><br class=""></span></td></tr></tbody></table><table width="635px" style="top: 2739px; width: 632px; height: 21px; left: 3px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><hr class=""></td></tr></tbody></table><table style="width: 632px; height: 531px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""> <strong style="color: rgb(19, 19, 19); font-family: arial, helvetica, sans-serif; text-transform: uppercase;" class=""><strong style="font-size: large;" class="">AROUND THE DEPARTMENT</strong></strong></td></tr><tr class=""><td style="border: 0px;" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOePCBrBT-2FYVsa11p0fB9wfJl8FnQplWq-2FtfpdEcnzOSbA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6XKPsEEjreZ4QM70llN4de8ZL-2F4vJp4hoBpLFYsDldcux15baetJP-2Fckrw9NF9vO7LZAI2ubRRSuMNFQEHooGKiv1MOPkmdXsaDSW9MC77fKI0IGlUeAwndj03mPjtAnc4a2RWSAP87SWvN60ZmAp5KoJAZWqadpxJ1by1nf5iSw-3D-3D" style="color: rgb(128, 0, 0);" class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/launch.jpg" alt="" width="635" height="402" class=""></a></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(143, 15, 40);" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOePCBrBT-2FYVsa11p0fB9wfJl8FnQplWq-2FtfpdEcnzOSbA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7f89zj-2FXawcWPytIedFhOvUnFy9asZQ6Rb7craAZxNDlS-2BWOi-2B1OmoNawF-2Baqmrf6aJSYP9Ejm58-2FNo5M-2Fy8PIuy1ueiL-2FLaR7QGka7s1OukefFjGNWaU-2BJXFLheJfvPN1TPZ0VJmhPnT275EcN92b89sQgzsFjgoBX9vj-2BeQtsQ-3D-3D" target="_blank" style="color: rgb(128, 0, 0); text-decoration: none;" class=""><span style="color: rgb(146, 32, 32);" class="">Have you seen the new face of MIT Biology?</span></a></span></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-size: 12px; font-family: arial, helvetica, sans-serif;" class="">We are pleased to announce the launch of our redesigned, reimagined, and revamped website. </span></td></tr><tr class=""><td style="border: 0px;" class=""> </td></tr></tbody></table><table style="width: 644px; height: 63px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe-2FGhF-2FIzoUNYBnF0NMl4OqoPicE67xbKbDZv0fxAwo0E-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7EH3-2BjGOqu9uahASXEkjm4TTCYR7uZJpKCx2EmpmWv-2BZj5T74H9F6Lkr07j9EGsCNFqxgJEVsttjbPkJAeJy-2F3at9D-2BJupKCmEYHCgqlW2b2XGVzaNHJwmv13nHOJ-2F51aNXUuApmkSOyfT0AfcT-2BkYU-2B6vReml9JdiYnmFcUKjdQ-3D-3D" style="color: rgb(128, 0, 0);" class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/cpcm-members.jpg" alt="" width="635" height="402" class=""></a></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(143, 15, 40);" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe-2FGhF-2FIzoUNYBnF0NMl4OqoPicE67xbKbDZv0fxAwo0E-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4RP1OGg4VIi9YTzttA6fC5hI7CLwRSfQwxtXQnGWxwDNuEAXEyDEgonYRe5y7LxNnjt-2FeU6lPZ8T1dRNlaeXoFqghXMgOiRpJPj8-2B0eIs6k5ORYMvXOV5F76024c7ZqnVCpfDOeOBJNXPHSnhDautP5ChkeLlkbVq-2FEwIs1w7WjA-3D-3D" target="_blank" style="color: rgb(128, 0, 0); text-decoration: none;" class=""><span style="color: rgb(146, 32, 32);" class="">Fine-tuning cancer medicine</span></a></span><br class=""></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-size: 12px; font-family: arial, helvetica, sans-serif;" class="">The Koch Institute for Integrative Cancer Research recently announced the launch of its new Center for Precision Cancer Medicine (CPCM). The center brings together leading Institute faculty members to focus on key research themes to accelerate the clinical translation of novel cancer discoveries, treatments, and technologies.</span></td></tr><tr class=""><td style="border: 0px;" class=""> </td></tr></tbody></table><table style="width: 644px; height: 402px; top: 2366px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeQeQ1y3lmKLoX-2BrDGVogvzM52J-2FAUVrfehHzigZ2KZpI-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7XeoVpt5wruFEys7-2BvabC2C5kT9P1N6f5qwTzMXEHE7ws-2F1KKjC2SVPjsMQcD71zPJgnb1B0E0VrPw1vKw6TIQNNrwbGkWsyfWAi3KsigS8aX3hVSWN3qSazyFER4Mf1GzaScFiwNjTuUBes5KyENLygNBNzvL-2B4jIST5vtEV2ww-3D-3D" style="color: rgb(128, 0, 0);" class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/george_church_lecture.jpeg" alt="" width="635" height="402" class=""></a></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(143, 15, 40);" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeQeQ1y3lmKLoX-2BrDGVogvzM52J-2FAUVrfehHzigZ2KZpI-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7Ct-2BbiiYJ5LtCPsLm6S6YBn5BbV1k1Pu-2BN3qcsDIux1XkEOwQ4R4TrCZEJoEYi3hR-2B67o14JPi5rFa5nqUJ41aaA00teJJWt8InyrCkFSRZU5o18fpM8dnL7Q4zEUlvlHpOvNVp-2Fbr-2FmtX3EpVZ1atlFhchCPElVY7a6Sbvf19zw-3D-3D" target="_blank" style="color: rgb(128, 0, 0); text-decoration: none;" class=""><span style="text-decoration: none; color: rgb(146, 32, 32);" class="">Reading and writing DNA</span></a></span></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-size: 12px; font-family: arial, helvetica, sans-serif;" class="">We invited pioneer of synthetic biology, George Church, to kick off our IAP seminar series, “Biology at Transformative Frontiers,” and speak about his work reading, writing, and editing the genome. The future, as he sees it, sounds a bit like something out of a sci-fi novel.</span></td></tr><tr class=""><td style="border: 0px;" class=""> </td></tr></tbody></table><table style="width: 642px; height: 522px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeiBcff-2FjEVVJnL-2BKJlxg-2BqhPorumPCmSRUDsvHZxPCsA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7jOYU18v-2BM9vnqGAVP0VUNtLhyM2SpyVJtJH88W1YpyA3W9TPLZ0dU-2B-2FKj2MVXRo1m9fQcGpK7Rkur81eOoAQSA7NrCdCw0iHd9-2FTgvNoSj-2B0W-2BEPc0X4k50iaAfluhID1h9JVFfNu-2B3qvoQxUYPTerKS5R-2B6vyV1JqHM7A4d1pQ-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/justin_chen.jpg" alt="" width="634" height="401" class=""></a></td></tr><tr class=""><td style="border: 0px;" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeiBcff-2FjEVVJnL-2BKJlxg-2BqhPorumPCmSRUDsvHZxPCsA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4f5EYewTZdd-2BEP3Tv85f-2FXTgkjGRE5lWFXFsCAo8PvuEVSb6tuvWahvIrdHgGlHraylgnfA4xHKZ-2FuKR-2Fy6ogZh7DcFJ34D5QkO792gjjRXIFWXG5LY4pFWSOP66eJyPxuwRSZJ-2BtmG5e3IYv0cTkfIWqWgJa7W-2BgJ8q9k1QVDYQ-3D-3D" target="_blank" style="color: rgb(128, 0, 0); text-decoration: none;" class=""><span style="font-family: arial, helvetica, sans-serif; font-size: 24px; color: rgb(143, 15, 40);" class="">Face Time</span></a></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-size: 12px; font-family: arial, helvetica, sans-serif;" class="">Newly minted PhD,<span class="Apple-converted-space"> </span><strong class="">Justin Chen</strong>, reflects on his experience in Hazel Sive’s lab studying developmental biology — investigating the complex beauty of how a face emerges from embryonic tissue. In his own words, "How nature makes something from almost nothing."</span></td></tr><tr class=""><td style="border: 0px;" class=""> </td></tr></tbody></table><table style="width: 639px; height: 508px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><span style="font-size: 16px;" class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/undergradsymposium.jpg" alt="" width="638" height="401" class=""></span></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-size: 12px; font-family: arial, helvetica, sans-serif;" class="">In early February, the department hosted its annual Undergraduate Research Symposium, featuring nine students doing biology-related UROPs around the Institute. Later that month, we welcomed prospective graduate students to campus for two open houses involving faculty talks, student panels, interviews, and other events.<span class="Apple-converted-space"> </span></span></td></tr><tr class=""><td style="border: 0px;" class=""> </td></tr></tbody></table><table style="width: 642px; height: 321px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeeetjRvohcxwq2WWgMBc0j3sfacJlRzbTmH6rDfljlEo-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6geOXG1fRKWRoQsQUL56OSgtj6vkfeKJBMQR1yD6ZbBffL4O6nEhj7NIOKcZQlY6dvnywSszjKpxZIylhYD-2F9TrGCEfIz3DC3jLFxnyUVPv0FR-2B6NgEtnVU-2FcoiB4IDoz93FscNynPIPSdyQEU7kuC1q-2FzGG-2BiQEvacL5VgmI-2FRw-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/infinitek2.jpg" alt="" width="635" height="257" class=""><br class=""></a></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-size: 12px; font-family: arial, helvetica, sans-serif;" class="">Postdoctoral fellows<span class="Apple-converted-space"> </span><strong class="">Lydia Herzel</strong><span class="Apple-converted-space"> </span>and<span class="Apple-converted-space"> </span><strong class="">Peter Sudmant</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeeetjRvohcxwq2WWgMBc0j3sfacJlRzbTmH6rDfljlEo-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5L0HJmGOcyCDLQr7gxx6nTnXamjNKfCioQ3G7wM-2FirspVSSp3OasoEQG9CSFx02mtYWiHW4JZF9uvUIJvpER6gcPPhy9AWWGCZI15D-2BWEjCLTFC8X5AlxJvwHa7giPkJN6EPTugN6mppELbq09SwZzpFXcCzPhMkvmZlD6jzJ22w-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">received</a><span class="Apple-converted-space"> </span>Infinite Kilometer Awards for their mentorship, participation in educational programs, and contributions to the MIT Postdoctoral Association and greater MIT community.</span></td></tr></tbody></table><table width="635px" style="width: 635px; height: 21px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><hr class=""></td></tr></tbody></table><table style="width: 641px; height: 59px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><strong style="font-family: arial, helvetica, sans-serif; font-size: large;" class="">RESEARCH HIGHLIGHTS</strong><br class=""></td></tr><tr class=""><td style="border: 0px;" class=""><em class=""><span style="font-size: 13px;" class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/research_triptych2.jpg" alt="" width="631" height="201" class=""><br class=""></span></em></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-family: arial, helvetica, sans-serif;" class=""><em class=""><span style="font-size: 13px;" class="">What follows is a sampling of recently published research across the department — for a more complete list of publications, click<span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOerPNi0ZiRCh0IX085MYFUwdbC1nRk1YehGmzmCBY-2BlT4-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6orxhb3fmwEBmoEi2xJUuQ3S5TnymBc1MSM-2B8oGnD0ZiD3s0s8CRlcDDZiWBWmJ3VGhrzJfbifqLY4UhThKdhKjlychba-2FFBqpmh71ItHA3EpeTiqEJBtB8oEVCdFBfoshzBbRo6m7AAPxJ-2BxE8qCAm9BWbkjpzQKxC3kNxssSpQ-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">here</a>. If there is a paper you would like to see highlighted in the next issue of the newsletter, please email<span class="Apple-converted-space"> </span><a href="mailto:mcelvery@mit.edu" style="color: rgb(128, 0, 0);" class="">mcelvery@mit.edu</a><span class="Apple-converted-space"> </span>or<span class="Apple-converted-space"> </span><a href="mailto:vivians@mit.edu" style="color: rgb(128, 0, 0);" class="">vivians@mit.edu</a>.</span></em></span></td></tr><tr class=""><td style="border: 0px;" class=""> </td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-size: 12px; font-family: arial, helvetica, sans-serif;" class="">Graduate student<span class="Apple-converted-space"> </span><strong class="">David Phizicky</strong><span class="Apple-converted-space"> </span>and Professor<span class="Apple-converted-space"> </span><strong class="">Steve Bell</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeqazAihGBOOjPbTU1GY6u92SSSNBfUal6t3lva44eu1M-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4W9ZEV2G31IxnBImmtyl4M29Ef-2BTS9UgkwDgEE3t4tjMqwgSo9e6x-2BlYIqOtUvE8eMaLt7EpixXniBUld8-2BgI-2F1Ui0EbPmHb6VBExnYureEFXI7PBBcjRL-2FFugFhoeLhnGyxd8-2BZc5LJ-2Fu2dmdgUBRUgDYH1BZkWVll8Jyy8G07A-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">investigated</a><span class="Apple-converted-space"> </span>how DNA replication is inhibited between meiotic divisions, revealing that multiple kinases inhibit both helicase loading and activation between divisions to ensure reductive cell division.<br class=""><br class="">Professor<span class="Apple-converted-space"> </span><strong class="">Eliezer Calo</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeJSkquWTvaQuvzYGAX-2BJA9GC9zi0Mb7GSQcrbQ7dRAlE-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7tpjwR-2Badex0sr9Yj38RJkCS9dvTY-2Bkrqv0-2FSe8TvZ0wBYT4Zx8sqHt4vyRJ7EgXHegoL6z9JE8V5jndl4CttfAnYbu9VB-2BVmVJSuZtWS3tZ82jJNatix9rkEtRnc4tDCvUCND05OrGqCQ8r-2BdcqEtt-2Fn0vZBwq8cQSE2HKvE4ug-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">explored</a><span class="Apple-converted-space"> </span>the molecular functions of DDX21, a DEAD-box RNA helicase, uncovering a previously unappreciated mechanism linking nucleolar dysfunction, ribosomal DNA damage, and craniofacial malformations.<span class="Apple-converted-space"> </span><br class=""><br class="">Postdoctoral researcher<span class="Apple-converted-space"> </span><strong class="">Raheleh Rezaei Araghi</strong><span class="Apple-converted-space"> </span>and Professor<span class="Apple-converted-space"> </span><strong class="">Amy Keating</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeqe1gSTOpgLyxZ1idkyqEYVwCMR9jhHnNztO0TaSI1nE-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5YgJDhgeqgYXQrn3OUysnD-2B6okyKXA6uBBpNOi5gNdTYPac88TYl-2BYYAGRSCO9dGNd9-2FL5-2BgTTfJVLMAY2vt8KVeYDmdrlOKr8UrEF-2FnBxDxxd2Y-2FAFDIblJkGFS1Yea1ka0P0Zv9rxNMlpkKvMfNSiCc7gj62D8ruxMC7FHSrkQ-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">modified</a><span class="Apple-converted-space"> </span>a key cancer survival protein called Mcl-1 to selectively kill cancer cells, and demonstrated how systematic optimization can transform a lead peptide into a drug prototype suitable for diagnostic and therapeutic development.<br class=""><br class="">Research assistant<span class="Apple-converted-space"> </span><strong class="">Saima Sidik</strong>, postdoctoral researcher<span class="Apple-converted-space"> </span><strong class="">Diego Huet</strong>, and Professor<span class="Apple-converted-space"> </span><strong class="">Sebastian Lourido</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOefHAYBLclXRKWPCVhioYEnUV32IwMt-2B3uo2VtG6P7u7E-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE6Nmm8THtgKRFcgZ-2B5tTGlJehES8qkHqqruhc9ZTcc2RcfhKtAjRA-2BMqFnoxiUOG6jp1DZeyyY9JhBSO1RcwHQTiYLtzV8mBqzXujd9JSoVJGafTkhv1seWEGr4U4wdfpZpS-2F4pz4jvSA1d4xtvJSiW3FxuZxL326j5ELbP8WiLvQ-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">employed</a>CRISPR-Cas9 to disrupt all nuclear protein–coding genes in <em class="">T. gondii</em> using a pooled format, presenting a workflow that permits a genome-wide screen and analysis in just three weeks.<br class=""><br class=""><em class="">Proceedings of the National Academy of Sciences</em> published a<span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeEUBzBPCo4wN8g0Xq2neHBh6nwQuqckxd4cnYQB7eTew-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5mPTvBWBx4E9fIdn3WeT0OOJ4XN2mipXQ1EqlQcfbo-2BXvUiK5FKozZ1G5buzEJTi4-2FCOHExLtfZg9Xzn3joESBeTPDZ0Q7zJDbD16mePTDbUYY8-2BYYB-2FdDN0s97-2F4PULatykoZ-2FAQ0LNHMR2-2BmefaqqnUMmu4bshyat-2BDox8YpnQ-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">profile</a><span class="Apple-converted-space"> </span>of<span class="Apple-converted-space"> </span><strong class="">David Sabatini</strong>, chronicling his research developments related to the mTOR pathway.<br class=""><br class="">Graduate student<span class="Apple-converted-space"> </span><strong class="">Grace Chen</strong><span class="Apple-converted-space"> </span>and Professors<span class="Apple-converted-space"> </span><strong class="">Hazel Sive</strong><span class="Apple-converted-space"> </span>and<span class="Apple-converted-space"> </span><strong class="">David Bartel</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeNtLI7fdQLAFSO3QR9rkQfjjgLcZ3Icz79iPyrbENZcY-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4bc7jyMTIvGaJOD2o8mdLoX12Jt64OKFB0WEWK-2FILv8Tz1nJw0YwYm8EZH3kHBEcKu9g35Pil46JmVNGbxb2ZIV8CrEhXQjLa2pZlYOja4sRTuW6RB-2Fu5IrzEm4k0ua2bDdu8ervg6Jj6n6vZVd9JTouGDCFO4gmqfMokkFw5pFw-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">determined</a><span class="Apple-converted-space"> </span>that RNAi is less effective in zebrafish partly because Argonaute2-catalyzed mRNA slicing is impaired — providing a strategy for restoring RNAi using a microRNA generated by a cleavage reaction analogous to slicing.<br class=""><br class="">New Assistant Director of the Cryogenic Electron Microscopy (cryo-EM) Facility<span class="Apple-converted-space"> </span><strong class="">Ed Brignole</strong>, Professor Emerita<span class="Apple-converted-space"> </span><strong class="">JoAnne Stubbe</strong>, and Professor<span class="Apple-converted-space"> </span><strong class="">Cathy Drennan</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeMuk5cfd7Y8noMGqXY1ggdbtiYjFZ7Mu6YWw9E9drNkQ-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE5B4aFMf01zEXFKcZNsJNrVMSySwhTYDgPGOsBC13WDlZZnL0EAbrbUvqX5hzEy1B0A6aw5VwDgdFuk5Id3iDbhEAAlZ-2FRhNsQPMu6EqIc0bKCYGk1dGJ7kI-2FHrq7xQPE-2ByXMpyekbxOE0lLUU3PgkBmCltPZaf7pr4c9vVzCCUgA-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">presented</a><span class="Apple-converted-space"> </span>a 3.3-Å resolution structure using cryo-EM of a dATP-inhibited state human ribonucleotide reductase (RNR), providing a model for RNR inhibition with ramifications for new anticancer and antibacterial drugs.<br class=""><br class="">Former research scientist<span class="Apple-converted-space"> </span><strong class="">Akiko Wagatsuma</strong><span class="Apple-converted-space"> </span>and Professor<span class="Apple-converted-space"> </span><strong class="">Susumu Tonegawa</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeN06iGf-2BMwLLeA6iKXduRJr7t5Yo7mymrg-2BHlQCbJVxA-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4TKcz-2FYNYLsN8VgoOYRTGAyXAP-2FVhs5iSFhuueA7t3aXRk86pAOAoOHCJExxpFZ8pZp-2BhzhJ2QZNs0Pz9P6ea4qBHdcjgd-2B9iGx1BKXA-2BdJ7S-2BcwY3A78-2BXFI6zL9eLVUAfFv-2B-2F-2FTnmQEgtEfcXFERtPTCripLLwYNbNhCfHoN9g-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">demonstrated<span class="Apple-converted-space"> </span></a>that locus coeruleus neuromodulation, especially to the CA3 subregion, plays a crucial role in memory formation of a new context.<br class=""><br class="">Current postdoctoral researcher<span class="Apple-converted-space"> </span><strong class="">Shawn Liu</strong>, former postdoc<span class="Apple-converted-space"> </span><strong class="">Hao Wu</strong>, Professor<span class="Apple-converted-space"> </span><strong class="">Richard Young</strong>, and Professor<span class="Apple-converted-space"> </span><strong class="">Rudolf Jaenisch</strong><span class="Apple-converted-space"> </span><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOe0XORYLvwwJv6yhoEpAm1vJhnW-2B3d7z-2FS5jIcFhUnu-2Bk-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE7mfG2UewbcTO9hu2WAiEzrFg5ucbrDku1OaBml-2Bcg7meaJcMOVKhiXlgfkXs4kDoB090LyZjbWJh7fX-2FqFPDtuVfsff5Eem5waSdkggcZ7d81ASckwsAemEY2IO7wkYudyp15xzFbf684dUlR7LiV08GHqlnAqH1zfuXGZ3nksbA-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">developed</a><span class="Apple-converted-space"> </span>DNA methylation editing tools to reverse the hypermethylation of the FMR1 gene, reactivating it and rescuing neurons affected by fragile X syndrome.<br class=""><br class="">Visiting scientist<span class="Apple-converted-space"> </span><strong class="">Nick Kwiatkowski</strong>, postdoctoral researcher<span class="Apple-converted-space"> </span><strong class="">Brian Abraham</strong>, and Professor<span class="Apple-converted-space"> </span><strong class="">Richard Young</strong><a href="http://emclick.imodules.com/wf/click?upn=hpP9iphrV3FXP2t3GxIpBAhX-2FHAG0tsEWICDz1533JtH7anuH5Q6I17ZcmTd5yOeyxpDvCYCdVE1T1C7djnpoAIWyyHBhqMA2uWcG5RxW-2Bg-3D_sSdFxsi8XqAVFReutGbSRrrYYr5L-2FmghKvZ3cw-2BVQ3ZgT6RM3K1IE3JNLQMw-2FdMrXnl5horULq2JrYTirLfouktVj-2FbpNoRzn-2FNnexr2xz-2FyunbegaFa557U3Yd3aOBvmGv7ysA49gtuVBKNIQ5dgJUffPzkZVe9-2FbYCAi2-2B6eleVnn3EzDE8Y-2Bt1mbNkV2-2BdAJ514X0-2FY-2Ftnkr-2BLH3DXWpyzFb8p9fuk5ouzRyAkBMm8he2jA80ifMrkMAnmev6TbgTDh1Z1GZQ1QpX13WQOQAp2fQx3J7oJhaDN2WoHE4Sk-2BPYwa0HkFZs7qMem9vD2f6jUX4hjCTIwaS9sM1-2BqRSHHdMowrklUsCqSrajKOt27GCHt-2BShh22nd-2BkY8EPg8-2F51Hqlz1HDj2wBoYomqtrbbJ3bnFZTethcCjq09WPrbXnzd4kIbeio9J-2FXN748N9FJ2Bp77OKhYgouivVJqmA-3D-3D" target="_blank" style="color: rgb(128, 0, 0);" class="">determined</a><span class="Apple-converted-space"> </span>that Ewing sarcoma cells are highly sensitive to CDK7/12/13 inhibitors, and the combination of these molecules with PARP inhibitors shows prominent synergy in multiple models of the disease.</span></td></tr></tbody></table><table width="635px" class=""><tbody class=""></tbody></table><table width="635px" style="top: 4427px; width: 644px; height: 21px; left: 2px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><hr class=""></td></tr></tbody></table><table width="635px" class=""><tbody class=""></tbody></table><table style="width: 631px; height: 548px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""> <strong style="color: rgb(19, 19, 19); font-family: arial, helvetica, sans-serif; font-size: 18px; text-transform: uppercase;" class=""><strong style="font-size: large;" class="">SAVE THE DATE</strong></strong></td></tr><tr class=""><td style="border: 0px;" class=""><img src="http://mit.imodules.com/s/1314/images/gid13/editor/biology_enews_/24hrgivingchallenge.jpg" alt="" width="635" height="402" class=""></td></tr><tr class=""><td style="border: 0px;" class=""> <span style="font-size: x-large; font-family: arial, helvetica, sans-serif; color: rgb(143, 15, 40);" class="">Pi Day 24-Hour Giving Challenge</span></td></tr><tr class=""><td style="border: 0px;" class=""><span style="font-size: 12px; font-family: arial, helvetica, sans-serif; color: rgb(19, 19, 19);" class="">On March 14, MIT will oversee its second annual 24-hour Day of Giving Challenge. If 25 individuals donate to the Department of Biology by Noon ET, it will unlock a $7,500 matching gift from our generous challenger, Susan Whitehead. Please contact our Development Officer <a href="mailto:degriff@mit.edu" style="color: rgb(128, 0, 0);" class="">Daniel Griffin</a> with any questions.</span></td></tr></tbody></table><table width="635px" style="width: 601px; height: 0px;" class=""><tbody class=""></tbody></table></div></div><div style="clear: both;" class=""><div class=""><table width="635px" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><hr class=""></td></tr><tr class=""><td style="border: 0px; padding: 0px 0px 10px;" class=""><table style="width: 626px; height: 77px;" class=""><tbody class=""><tr class=""><td style="border: 0px;" class=""><p class=""><span style="font-size: 16px;" class=""><span style="background-color: rgb(255, 255, 255); font-family: "Maven Pro Black", Arial, Helvetica, sans-serif;" class="">MIT Department of Biology</span><span style="" class=""><br style="font-family: "Maven Pro Black", Arial, Helvetica, sans-serif; background-color: rgb(0, 82, 147);" class=""><span style="background-color: rgb(255, 255, 255); font-family: "Maven Pro Black", Arial, Helvetica, sans-serif;" class="">77 Massachusetts Avenue, 68-132</span><br style="font-family: "Maven Pro Black", Arial, Helvetica, sans-serif; background-color: rgb(0, 82, 147);" class=""><span style="background-color: rgb(255, 255, 255); font-family: "Maven Pro Black", Arial, Helvetica, sans-serif;" class="">Cambridge, MA 02139</span></span></span></p><p class=""><span style="background-color: rgb(255, 255, 255); font-family: "Maven Pro Black", Arial, Helvetica, sans-serif; font-size: 10px;" class=""><a 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