[bioundgrd] FW: Microbiome Club Postdoc Seminar 12/17 @ 5:30 PM, 56-614

[Joshua Stone]

From: Chelsea Catania <cataniac at mit.edu>
Subject: Microbiome Club Postdoc Seminar 12/17 @ 5:30 PM, 56-614

MIT Microbiome Club
Postdoc/Student Seminar Series
[cid:DE188664-4E8D-43E8-AA08-7505B7991C01 at broadinstitute.org]
 Jay Worley, M.D.
Genomic origins and clinical risks of asymptomatic C. difficile carriage
Monday, December 17th at 5:30 PM in 56-614 (RSVP<https://www.facebook.com/events/1949981431976125/>)
Affiliation: Bry Lab, Brigham and Women’s Hospital. ORISE Fellow, National Center for Biotechnology Information
Clostridioides difficile is a leading cause of health care-associated infection in the United States and the leading cause of death from a gastrointestinal pathogen. The annual costs associated with its treatment are frequently estimated to be in excess of $5 billion. We designed an experiment to address if patients who develop hospital-onset C. difficile infection (CDI) were infected by strains commonly found at the hospital, from other patients, or asymptomatically carried upon admission. We repurposed swabs for vancomycin resistant enterococci from the intensive care units for a C. difficile screen lasting 5 months. Additionally, we collected all toxin-positive stool samples for C. difficile isolation over an 8 month period including one and a half months before and after the swab collection period. We sequenced the genomes of all isolates collected. Over 1800 patients were screened for C. difficile in the intensive care units at BWH. 175 isolates were obtained from stool samples and 173 from swabs.
Asymptomatic carriage is a significant risk for C. difficile disease. We show that the C. difficile isolates found at the hospital during this period are diverse, but several cases of potential patient-to-patient transmission were found, including asymptomatic carriage. Patients who are infected with one strain can carry that strain over an extended period of time. Follow up studies on antibiotic resistance are laying the groundwork for new insights into C. difficile biology and pathogenesis. These findings show that screening for C. difficile could be useful and economical for identifying patients for contact precautions and decreasing disease onset through limiting antibiotic use or decolonization.
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The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine. Learn more on our Facebook page. <https://www.facebook.com/MITmicrobiomeclub/> Or follow us on Twitter<https://twitter.com/MITubiomeclub>.

Chelsea Catania, Ph.D.
MIT Microbiome Club President
Postdoctoral Associate
Laboratory for Energy and Microsystems Innovation
Department of Mechanical Engineering
@MITubiomeclub<https://twitter.com/MITubiomeclub>

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