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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Chelsea Catania <cataniac@mit.edu><br>
<b>Subject: </b>Microbiome Club Postdoc Seminar 12/17 @ 5:30 PM, 56-614<o:p></o:p></span></p>
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<span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">MIT Microbiome Club </span><o:p></o:p></p>
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<span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">Postdoc/Student Seminar Series</span><o:p></o:p></p>
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<img width="150" height="146" style="width:1.5625in;height:1.5208in" id="_x0033_11880ED-B5D4-4471-9323-D418DD3D0F6A" src="cid:image001.jpg@01D49083.8524E450" alt="cid:DE188664-4E8D-43E8-AA08-7505B7991C01@broadinstitute.org"><o:p></o:p></p>
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<b><span style="font-size:27.0pt;font-family:"Avenir Book";color:#28916B"> Jay Worley, M.D.</span></b><o:p></o:p></p>
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<i><span style="font-size:27.0pt;font-family:"Avenir Book";color:#28916B">Genomic origins and clinical risks of asymptomatic C. difficile carriage</span></i><o:p></o:p></p>
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<span style="font-size:24.0pt;font-family:"Avenir Book";color:#3A3E44">Monday, December 17th at 5:30 PM in 56-614
</span><span style="font-size:18.0pt;font-family:"Avenir Book";color:#3A3E44">(<a href="https://www.facebook.com/events/1949981431976125/">RSVP</a>)</span><o:p></o:p></p>
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<span style="font-size:11.5pt;font-family:Avenir-Book">Affiliation: Bry Lab, Brigham and Women’s Hospital. ORISE Fellow, National Center for Biotechnology Information</span><o:p></o:p></p>
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<span style="font-size:11.5pt;font-family:Avenir-Book">Clostridioides difficile is a leading cause of health care-associated infection in the United States and the leading cause of death from a gastrointestinal pathogen. The annual costs associated with its
treatment are frequently estimated to be in excess of $5 billion. We designed an experiment to address if patients who develop hospital-onset C. difficile infection (CDI) were infected by strains commonly found at the hospital, from other patients, or asymptomatically
carried upon admission. We repurposed swabs for vancomycin resistant enterococci from the intensive care units for a C. difficile screen lasting 5 months. Additionally, we collected all toxin-positive stool samples for C. difficile isolation over an 8 month
period including one and a half months before and after the swab collection period. We sequenced the genomes of all isolates collected. Over 1800 patients were screened for C. difficile in the intensive care units at BWH. 175 isolates were obtained from stool
samples and 173 from swabs. </span><o:p></o:p></p>
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<span style="font-size:11.5pt;font-family:Avenir-Book">Asymptomatic carriage is a significant risk for C. difficile disease. We show that the C. difficile isolates found at the hospital during this period are diverse, but several cases of potential patient-to-patient
transmission were found, including asymptomatic carriage. Patients who are infected with one strain can carry that strain over an extended period of time. Follow up studies on antibiotic resistance are laying the groundwork for new insights into C. difficile
biology and pathogenesis. These findings show that screening for C. difficile could be useful and economical for identifying patients for contact precautions and decreasing disease onset through limiting antibiotic use or decolonization.</span><o:p></o:p></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-family:"Avenir Book";color:black">______________________________ </span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><i><span style="font-family:"Avenir Book";color:#16191F">The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT
undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine.<a href="https://www.facebook.com/MITmicrobiomeclub/"><span style="color:#16191F"> </span><span style="color:#386EFF">Learn
more on our Facebook page. </span></a>Or follow us on </span></i><span style="color:black"><a href="https://twitter.com/MITubiomeclub"><i><span style="font-family:"Avenir Book"">Twitter</span></i></a></span><i><span style="font-family:"Avenir Book";color:#16191F">. </span></i><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-family:Avenir-Book;color:black">Chelsea Catania, Ph.D.</span></b><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">MIT Microbiome Club President</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Postdoctoral Associate</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Laboratory for Energy and Microsystems Innovation</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Department of Mechanical Engineering</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">@<a href="https://twitter.com/MITubiomeclub">MITubiomeclub</a> </span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="color:black"><a href="http://mailman.mit.edu/mailman/options/microbiome-club"><span style="font-family:Avenir-Book">Unsubscribe</span></a><o:p></o:p></span></p>
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