[bioundgrd] UROP position available in Bartel lab

[Joshua Stone]

From: Wenwen Fang <wfang at wi.mit.edu<mailto:wfang at wi.mit.edu>>

Students should contact Wenwen Fang (wfang at wi.mit.edu<mailto:wfang at wi.mit.edu>) directly.


Project Title: MicroRNA biogenesis
Project Description: MicroRNAs are ~ 22 nt endogenous RNAs that target mRNA post-transcriptionally to decrease protein output.  A mammalian genome encodes hundreds of microRNAs, which collectively regulate the majority of the transcriptome.  Accumulating evidence suggests that microRNAs play key roles in diverse biological processes.  This project aims at understanding the molecular mechanism by which microRNAs are made.  The UROP will work closely with Wenwen Fang, a postdoc researcher in the lab with extensive training in molecular biology and biochemistry. The UROP will participate in and learn about culturing human or mouse cells, and generating cell lines by CRISPR technology; perform biochemical and imaging experiments; prepare next generation sequencing libraries and carry out data analysis.

Prerequisites: self-motivated student, general biology course (understanding of general biology), previous research experience preferable.

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