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<p class="MsoNormal"><b><span style="font-family:Helvetica">From: </span></b><span style="font-family:Helvetica">Wenwen Fang <<a href="mailto:wfang@wi.mit.edu">wfang@wi.mit.edu</a>></span><o:p></o:p></p>
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<p class="MsoNormal">Students should contact Wenwen Fang (<a href="mailto:wfang@wi.mit.edu">wfang@wi.mit.edu</a>) directly.<o:p></o:p></p>
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<p style="text-indent:.5in;background:white"><strong><span style="font-family:"Arial",sans-serif;color:#222222">Project Title:</span></strong><span style="font-family:"Arial",sans-serif;color:#222222"> MicroRNA biogenesis</span><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></p>
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<p class="MsoNormal"><strong><span style="font-family:"Arial",sans-serif;color:#222222">Project Description:</span></strong><span style="font-family:"Arial",sans-serif;color:#222222"> MicroRNAs are ~ 22 nt endogenous RNAs that target mRNA post-transcriptionally
to decrease protein output. A mammalian genome encodes hundreds of microRNAs, which collectively regulate the majority of the transcriptome. Accumulating evidence suggests that microRNAs play key roles in diverse biological processes. This project aims
at understanding the molecular mechanism by which microRNAs are made. The </span><span style="font-family:"Arial",sans-serif">UROP<span style="color:#222222"> will work closely with Wenwen Fang, a postdoc researcher in the lab with extensive training in molecular
biology and biochemistry. The <span class="gmail-m-6160263011457086261gmail-il">UROP</span> will participate in and learn about culturing human or mouse cells, and generating cell lines by CRISPR technology; perform biochemical and imaging experiments; prepare
next generation sequencing libraries and carry out data analysis.</span></span><o:p></o:p></p>
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<strong><span style="font-family:"Arial",sans-serif;color:#222222">Prerequisites:</span></strong><span style="font-family:"Arial",sans-serif;color:#222222"> self-motivated student, general biology course (understanding of general biology), previous research
experience preferable. </span><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></p>
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