[bioundgrd] FW: TOMORROW MIT Microbiome Club Seminar, 3 PM, 56-614

[Joshua Stone]

From: Chelsea Catania <cataniac at mit.edu>
Subject: TOMORROW MIT Microbiome Club Seminar, 3 PM, 56-614

MIT Microbiome Club
Seminar Series
[cid:DE188664-4E8D-43E8-AA08-7505B7991C01 at broadinstitute.org]
Dr. David Riglar
Gut Feelings: Engineering Synthetic Bacterial Circuits to Probe the Mammalian Gut
Thursday, April 19th at 3 pm in MIT 56-614

Our ability to non-invasively interrogate the mammalian gut and its resident microbiota remains extremely limited. This has hindered our functional understanding of the gut, ultimately limiting the rational design of diagnostic and therapeutic clinical interventions for a range of gut diseases. Utilization of engineered bacteria to probe the gut has therefore been a long-held goal of synthetic biologists. I will discuss efforts to develop and use synthetic circuits within bacteria to record transient inflammatory signals and to better understand bacterial growth kinetics in situ within the mammalian gut. These results demonstrate the potential for engineered bacteria to stably and reliably probe functional aspects of the microbiota for which traditional sensors and diagnostics may not be feasible or cost-effective over extended periods. Given that the function and growth of the gut microbiota has been increasingly implicated in disorders as wide ranging as inflammatory disease, cancer, infectious disease and even mental health, these tools have the potential to ultimately benefit a large percentage of the human population.

______________________________
The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine. Learn more on our Facebook page. Or follow us on Twitter<https://twitter.com/MITubiomeclub>.

Chelsea Catania, Ph.D.
MIT Microbiome Club Communications Chair
Postdoctoral Associate
Laboratory for Energy and Microsystems Innovation
Department of Mechanical Engineering
@MITubiomeclub<https://twitter.com/MITubiomeclub>


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