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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Chelsea Catania <cataniac@mit.edu><br>
<b>Subject: </b>TOMORROW MIT Microbiome Club Seminar, 3 PM, 56-614<o:p></o:p></span></p>
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<a name="_MailOriginalBody"><span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">MIT Microbiome Club </span><o:p></o:p></a></p>
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<span style="mso-bookmark:_MailOriginalBody"><span style="font-size:18.0pt;font-family:"Avenir Book";color:#77984C">Seminar Series</span><o:p></o:p></span></p>
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<span style="mso-bookmark:_MailOriginalBody"><img width="150" height="146" style="width:1.5625in;height:1.5208in" id="B0E8DF32-5689-4F63-8860-173C84BA66E1" src="cid:image001.jpg@01D3D705.4DF22700" alt="cid:DE188664-4E8D-43E8-AA08-7505B7991C01@broadinstitute.org"><o:p></o:p></span></p>
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<span style="mso-bookmark:_MailOriginalBody"><b><span style="font-size:36.0pt;font-family:"Avenir Book";color:#28916B">Dr. David Riglar</span></b><o:p></o:p></span></p>
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<span style="mso-bookmark:_MailOriginalBody"><i><span style="font-size:36.0pt;font-family:"Avenir Book";color:#28916B">Gut Feelings: Engineering Synthetic Bacterial Circuits to Probe the Mammalian Gut</span></i><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="mso-bookmark:_MailOriginalBody"><span style="font-size:24.0pt;font-family:"Avenir Book";color:#3A3E44">Thursday, April 19<sup>th</sup> at 3 pm in MIT 56-614</span><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody"><span style="font-size:10.5pt;font-family:"Avenir Book";color:#453CCC"> </span></span><span style="mso-bookmark:_MailOriginalBody"><o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="mso-bookmark:_MailOriginalBody"><span style="font-size:10.5pt;font-family:"Avenir Book"">Our ability to non-invasively interrogate the mammalian gut and its resident
microbiota remains extremely limited. This has hindered our functional understanding of the gut, ultimately limiting the rational design of diagnostic and therapeutic clinical interventions for a range of gut diseases. Utilization of engineered bacteria to
probe the gut has therefore been a long-held goal of synthetic biologists. I will discuss efforts to develop and use synthetic circuits within bacteria to record transient inflammatory signals and to better understand bacterial growth kinetics <i>in situ </i>within
the mammalian gut. These results demonstrate the potential for engineered bacteria to stably and reliably probe functional aspects of the microbiota for which traditional sensors and diagnostics may not be feasible or cost-effective over extended periods.
Given that the function and growth of the gut microbiota has been increasingly implicated in disorders as wide ranging as inflammatory disease, cancer, infectious disease and even mental health, these tools have the potential to ultimately benefit a large
percentage of the human population. </span><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody"><span style="font-family:"Avenir Book";color:#453CCC"> </span></span><span style="mso-bookmark:_MailOriginalBody"><o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="mso-bookmark:_MailOriginalBody"><span style="font-family:"Avenir Book";color:#453CCC">______________________________ </span><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="mso-bookmark:_MailOriginalBody"><i><span style="font-family:"Avenir Book";color:#16191F">The MIT Microbiome Club, part of the Center for Microbiome Informatics and
Therapeutics, brings together inquisitive MIT undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine. </span></i></span><span style="mso-bookmark:_MailOriginalBody"><u><span style="font-family:"Avenir Book";color:#386EFF">Learn
more on our Facebook page. </span></u></span><span style="mso-bookmark:_MailOriginalBody"><i><span style="font-family:"Avenir Book";color:#16191F">Or follow us on </span></i></span><a href="https://twitter.com/MITubiomeclub"><span style="mso-bookmark:_MailOriginalBody"><i><span style="font-family:"Avenir Book"">Twitter</span></i></span><span style="mso-bookmark:_MailOriginalBody"></span></a><span style="mso-bookmark:_MailOriginalBody"><i><span style="font-family:"Avenir Book";color:#16191F">. </span></i><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody"><b>Chelsea Catania, Ph.D.</b></span><span style="mso-bookmark:_MailOriginalBody"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody">MIT Microbiome Club Communications Chair<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody">Postdoctoral Associate<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody">Laboratory for Energy and Microsystems Innovation<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody">Department of Mechanical Engineering<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-bookmark:_MailOriginalBody">@</span><a href="https://twitter.com/MITubiomeclub"><span style="mso-bookmark:_MailOriginalBody">MITubiomeclub</span><span style="mso-bookmark:_MailOriginalBody"></span></a><span style="mso-bookmark:_MailOriginalBody"> <o:p></o:p></span></p>
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