[bioundgrd] FW: MIT Microbiome Club - Seminar Series - Dr. Neeraj Surana

[Joshua Stone]

From: Jared Kehe <jkehe at broadinstitute.org>
Subject: MIT Microbiome Club - Seminar Series - Dr. Neeraj Surana

MIT Microbiome Club
Seminar Series
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Dr. Neeraj Surana:
A disease-protective human commensal discovered using microbial pedigree analysis

Thursday, March 23 from 4–5pm in Monadnock Room, Broad Institute 2nd Floor

PLEASE RSVP ON OUR EVENT PAGE<https://www.facebook.com/events/498200470374431/>


The MIT Microbiome Club will be hosting Dr. Neeraj Surana<http://www.childrenshospital.org/researchers/neeraj-surana>.

Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease pathogenesis. In order to move the field beyond correlations and to begin to address causation, an effective system is needed for refining this catalog of differentially abundant microbes for subsequent mechanistic studies. Herein, we demonstrate that principles of family pedigree analysis used in genetics can be applied in microbiota studies to reduce the noise inherent in these experiments. We found that gnotobiotic mice harboring different microbial communities exhibited differential survival in a colitis model. Co-housing of these gnotobiotic mice generated “progeny” that had hybrid microbiotas reflective of both “parents” and displayed intermediate susceptibility to colitis. Mapping of microbe­–phenotype relationships in parental mouse strains and in mice with hybrid microbiotas identified the bacterial family Lachnospiraceae as a correlate for protection from disease. Using directed microbial culture techniques, we discovered Clostridium immunis, a previously unknown bacterial species from this family, that—when administered to colitis-prone mice—protected against colitis-associated death. Thus, we have used “microbial pedigree” analysis to move beyond the standard correlative microbiome study and found a hitherto unidentified commensal that causally protects from colitis. More broadly, identifying disease-modulating commensals by means of microbial pedigree analysis may also be applicable to human microbiome studies. Learn more on the event page.<https://www.facebook.com/events/498200470374431/>

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The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT undergrads, grad researchers, postdocs, faculty, and clinicians in the emerging field of microbiome studies and microbiome-based medicine. Learn more on our Facebook page.<https://www.facebook.com/pg/MITmicrobiomeclub/about/?ref=page_internal>



–
Jared Kehe
NSF Graduate Student, MIT Biological Engineering
Blainey and Sabeti Labs, Broad Institute
Broad Research Comm Lab Fellow
jkehe at broadinstitute.org<mailto:jkehe at broadinstitute.org>








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