<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns:mv="http://macVmlSchemaUri" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Title" content="">
<meta name="Keywords" content="">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Avenir-Book;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
span.textexposedshow
{mso-style-name:text_exposed_show;}
span.EmailStyle18
{mso-style-type:personal-reply;
font-family:Calibri;
color:windowtext;
font-weight:normal;
font-style:normal;}
span.msoIns
{mso-style-type:export-only;
mso-style-name:"";
text-decoration:underline;
color:teal;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style>
</head>
<body bgcolor="white" lang="EN-US" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri"><o:p> </o:p></span></p>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-family:Calibri;color:black">From: </span>
</b><span style="font-family:Calibri;color:black">Jared Kehe <jkehe@broadinstitute.org><br>
<b>Subject: </b>MIT Microbiome Club - Seminar Series - Dr. Neeraj Surana<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:18.0pt;font-family:Avenir-Book;color:#89A65E">MIT Microbiome Club </span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:18.0pt;font-family:Avenir-Book;color:#89A65E">Seminar Series</span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:18.0pt;font-family:Avenir-Book;color:#2EA07E"><img width="150" height="146" id="AC1F4AD3-AB3E-403A-BD57-571F2882AF6C" src="cid:image001.jpg@01D29E51.2312F430"></span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:30.0pt;font-family:Avenir-Book;color:#2EA07E">Dr. Neeraj Surana:</span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:30.0pt;font-family:Avenir-Book;color:#2EA07E">A disease-protective human commensal discovered using microbial pedigree analysis</span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><o:p> </o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:13.5pt;font-family:Avenir-Book;color:#4A4F56">Thursday, March 23 from 4–5pm in Monadnock Room, Broad Institute 2nd Floor</span><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><o:p> </o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><a href="https://www.facebook.com/events/498200470374431/"><span style="font-size:15.0pt;font-family:Avenir-Book">PLEASE RSVP ON OUR EVENT PAGE</span></a><o:p></o:p></p>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:Avenir-Book;color:#4B4F56">The MIT Microbiome Club will be hosting <a href="http://www.childrenshospital.org/researchers/neeraj-surana">Dr. Neeraj Surana</a>.</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:Avenir-Book;color:#4B4F56;letter-spacing:-.2pt;background:white">Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These
studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease pathogenesis. In order to move the field beyond correlations and to begin to address causation, an effective system is needed for refining
this catalog of differentially abundant microbes for subsequent mechanistic studies. Herein, we demonstrate that principles of family pedigree analysis used in genetics can be applied in microbiota studies to reduce the noise inherent in these experiments.
We found that gnotobiotic mice harboring different microbial communiti</span><span class="textexposedshow"><span style="font-size:10.5pt;font-family:Avenir-Book;color:#4B4F56;letter-spacing:-.2pt">es exhibited differential survival in a colitis model. Co-housing
of these gnotobiotic mice generated “progeny” that had hybrid microbiotas reflective of both “parents” and displayed intermediate susceptibility to colitis. Mapping of microbe–phenotype relationships in parental mouse strains and in mice with hybrid microbiotas
identified the bacterial family Lachnospiraceae as a correlate for protection from disease. Using directed microbial culture techniques, we discovered Clostridium immunis, a previously unknown bacterial species from this family, that—when administered to colitis-prone
mice—protected against colitis-associated death. Thus, we have used “microbial pedigree” analysis to move beyond the standard correlative microbiome study and found a hitherto unidentified commensal that causally protects from colitis. More broadly, identifying
disease-modulating commensals by means of microbial pedigree analysis may also be applicable to human microbiome studies. </span></span><span style="font-family:Avenir-Book"><a href="https://www.facebook.com/events/498200470374431/"><span style="font-size:10.5pt">Learn
more on the event page.</span></a></span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:Avenir-Book">———</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><i><span style="font-family:Avenir-Book;color:#1D2129;background:white">The MIT Microbiome Club, part of the Center for Microbiome Informatics and Therapeutics, brings together inquisitive MIT undergrads, grad researchers, postdocs, faculty,
and clinicians in the emerging field of microbiome studies and microbiome-based medicine. </span></i><span style="font-family:Avenir-Book"><a href="https://www.facebook.com/pg/MITmicrobiomeclub/about/?ref=page_internal">Learn more on our Facebook page.</a></span><o:p></o:p></p>
</div>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-family:Avenir-Book"><br>
<br>
<br>
</span><o:p></o:p></p>
<div>
<div>
<div>
<div>
<div>
<div>
<div>
<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">–</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Jared Kehe</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">NSF Graduate Student, MIT Biological Engineering</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Blainey and Sabeti Labs, Broad Institute</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black">Broad Research Comm Lab Fellow</span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="font-family:Avenir-Book;color:black"><a href="mailto:jkehe@broadinstitute.org">jkehe@broadinstitute.org</a></span><span style="color:black"><o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
</div>
</div>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
</div>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
</div>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
</div>
<p class="MsoNormal"><span style="color:black"><o:p> </o:p></span></p>
</div>
<p class="MsoNormal" style="margin-bottom:12.0pt"><o:p> </o:p></p>
</div>
<p class="MsoNormal"><br>
<br>
<o:p></o:p></p>
</div>
</body>
</html>