[bioundgrd] FW: Biology 7.346 "Hunting for the Genes that Cause Brain Disorders and Aging" Mon430-630, 68-274

[Crystal Boateng]

Begin Forwarded Message:


From: "A. Zara Herskovits" <aherskov at mit.edu>


Dear Crystal,  Would it be possible to send out one (hopefully final) email for the semester to group 7 students because both the time and the room number were changed from what we initially planned and would hate to lose people going to the wrong place etc. Thanks for your help, Zara


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Biology 7.346  "Hunting for the Genes that Cause Brain Disorders and Aging"
Mondays 430-630pm
Building 68, Room 274

Course website:  https://stellar.mit.edu/S/course/7/fa16/7.346/



Neurological diseases are one of the most important medical challenges facing society today.  One in four people will have an episode of major depression in their lifetimes, and almost half of people over 85 years old have Alzheimer's disease.   This course will walk through how the first genes for monogenic neurodegenerative disorders, such as amyotrophic lateral sclerosis and Huntington's disease, were discovered using classical approaches.  We will continue through current studies, from which the genetic architecture of complex diseases such as schizophrenia are just being uncovered.  We will discuss how an individual's risk of developing a disease can be assessed from small genetic changes in nucleotide sequence and on larger structural variations that affect entire regions of a chromosome.  We will read papers from the primary scinetific literature to understand how genetics is informing the treatment of patients with neurological disorders.  Genomic anlaysis has spurred the development of new treatment strategies, such as antisense oligonucleotide therapies for diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis.  This course will combine discussions of primary scientific literature with hands-on data analysis and small group presentations. We will take a field trip to a local pharmaceutical company to learn about how new treatments for these neurological conditions are being developed.



PLEASE NOTE CHANGE IN MEETING TIME/LOCATION.  IF YOU ARE INTERESTED IN TAKING THIS COURSE,  PLEASE EMAIL THE INSTRUCTORS ( GLORIOSO at MIT.EDU <mailto:GLORIOSO at MIT.EDU> OR AHERSKOV at MIT.EDU <mailto:AHERSKOV at MIT.EDU> )  REGISTRATION IS STILL OPEN.  THANK YOU!
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