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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Calibri">Begin Forwarded Message:<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-family:Calibri;color:black">From: </span>
</b><span style="font-family:Calibri;color:black">"A. Zara Herskovits" <aherskov@mit.edu><br>
<br>
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<p><span style="font-size:10.0pt;font-family:Tahoma;color:black">Dear Crystal, Would it be possible to send out one (hopefully final) email for the semester to group 7 students because both the time and the room number were changed from what we initially planned
and would hate to lose people going to the wrong place etc. Thanks for your help, Zara<o:p></o:p></span></p>
<p><span style="font-size:10.0pt;font-family:Tahoma;color:black"> <o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:Tahoma;color:black">-------------------------------------</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><strong><span style="font-size:10.0pt;font-family:Tahoma;color:black">Biology 7.346 "Hunting for the Genes that Cause Brain Disorders and Aging"
</span></strong><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><strong><span style="font-size:10.0pt;font-family:Tahoma;color:black">Mondays 430-630pm</span></strong><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><strong><span style="font-size:10.0pt;font-family:Tahoma;color:black">Building 68, Room 274</span></strong><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><strong><span style="font-family:Tahoma;color:black">Course website: </span></strong><span style="font-family:Tahoma;color:black">
<a href="https://stellar.mit.edu/S/course/7/fa16/7.346/" target="_blank">https://stellar.mit.edu/S/course/7/fa16/7.346/</a></span><span style="color:black"><o:p></o:p></span></p>
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<p><span style="font-size:10.0pt;font-family:Tahoma;color:black"> <o:p></o:p></span></p>
<p><span style="font-size:10.0pt;font-family:Tahoma;color:black">Neurological diseases are one of the most important medical challenges facing society today. One in four people will have an episode of major depression in their lifetimes, and almost half of
people over 85 years old have Alzheimer's disease. This course will walk through how the first genes for monogenic neurodegenerative disorders, such as amyotrophic lateral sclerosis and Huntington's disease, were discovered using classical approaches. We
will continue through current studies, from which the genetic architecture of complex diseases such as schizophrenia are just being uncovered. We will discuss how an individual's risk of developing a disease can be assessed from small genetic changes in nucleotide
sequence and on larger structural variations that affect entire regions of a chromosome. We will read papers from the primary scinetific literature to understand how genetics is informing the treatment of patients with neurological disorders. Genomic anlaysis
has spurred the development of new treatment strategies, such as antisense oligonucleotide therapies for diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis. This course will combine discussions of primary scientific literature with
hands-on data analysis and small group presentations. We will take a field trip to a local pharmaceutical company to learn about how new treatments for these neurological conditions are being developed.<o:p></o:p></span></p>
<p><span style="font-size:10.0pt;font-family:Tahoma;color:black"> <o:p></o:p></span></p>
<p><strong><span style="font-size:10.0pt;font-family:Tahoma;color:black">PLEASE NOTE CHANGE IN MEETING TIME/LOCATION. IF YOU ARE INTERESTED IN TAKING THIS COURSE, PLEASE EMAIL THE INSTRUCTORS (</span></strong><span style="font-size:10.0pt;font-family:Tahoma;color:black">
<a href="mailto:GLORIOSO@MIT.EDU" target="_blank"><strong><span style="font-family:Tahoma">GLORIOSO@MIT.EDU</span></strong>
</a><strong><span style="font-family:Tahoma">OR</span></strong> <a href="mailto:AHERSKOV@MIT.EDU" target="_blank">
<strong><span style="font-family:Tahoma">AHERSKOV@MIT.EDU</span></strong> </a><strong><span style="font-family:Tahoma">) REGISTRATION IS STILL OPEN. THANK YOU!</span></strong>
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