[bioundgrd] Summer UROP: Human albumin by isotopic-labeled yeast

[Joyce Roberge]

 PI:
Jean-François Hamel, PhD
Office 66-371
E-mail: jhamel at mit.edu<mailto:jhamel at mit.edu>
Phone: (617) 258-6665

Proposed Summer UROP Project
Production of isotopically-enriched serum albumin for biomedical research using Pichia
pastoris as a biosynthetic host

Overall Objective:
The project focuses on the development and optimization of the substrate yield of a novel process
that uses [13C6]glucose and [15N2]ammonium sulfate to produce isotopically-labeled serum
albumin from the yeast Pichia pastoris, with robust and consistent quantity and enrichment for
biomedical research applications.







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