[bioundgrd] UROP positions in Lodish lab / Whitehead

[Joyce Roberge]

9/11/2013
 Fall 2013

Department/Lab/Center:  Whitehead Institute / Biology
Biology
Faculty Supervisor: Prof. Harvey Lodish
Project Title: Mechanisms of Mitochondrial Oxidative Stress Signaling


Project Description: Oxidative stress and mitochondrial dysfunction are linked to numerous diseases. The goal of this UROP project is to determine the role of metabolites and certain drugs in modulating oxidative stress signaling. The student will have the opportunity to learn mammalian cell culture and purification techniques and Western blotting with a possible extension to other techniques such as flow cytometry and confocal imaging. The student is expected to formally present the research in lab meeting. A senior post-doc in the lab will supervise the project.
Prerequisites: Prior laboratory experience in molecular biology is desired. The project is especially suited for biology majors in their senior year. Attention to detail and ability to keep an organized record of observations and results are essential.
Time: At least one full day and a subsequent half-day per week are required to perform the experiments. The successful applicant will commence the UROP over the fall semester and be encouraged to continue over the IAP period and subsequent semester with the possibility to transition into a full-time research technician position.
Contact: Interested applicants should send a CV to Heide Christine Patterson, MD (ckunst at wi.mit.edu<mailto:ckunst at wi.mit.edu>).

9/11/2013 
Fall 2013

Department/Lab/Center:  Whitehead Institute / Biology
Biology
Faculty Supervisor: Prof. Harvey Lodish
Project Title: Mechanisms of Mitochondrial Oxidative Stress Signaling


Project Description: Oxidative stress and mitochondrial dysfunction are linked to numerous diseases. The goal of this UROP project is to determine whether the signaling domain of a mitochondrial protein promotes signaling as part of a larger project characterizing the mechanisms of mitochondrial oxidative stress signaling. The student will have the opportunity to learn molecular biology, cell culture and transfection techniques as well as Western blotting. The student will be trained in critically evaluating the data and is expected to formally present the research in lab meeting. A senior post-doc in the lab will supervise the project.
Prerequisites: Prior molecular biology experience is desired but not required. Attention to detail and ability to keep an organized record of observations and results are essential.
Time: A time commitment of at least 8 hours per week during the semester is expected. The successful applicant will commence the UROP over the fall semester and be encouraged to continue over the IAP period and subsequent semesters.
Contact: Interested applicants should send a CV to Heide Christine Patterson, MD (ckunst at wi.mit.edu<mailto:ckunst at wi.mit.edu>).

*****************

Heide Christine Patterson, MD
Instructor in Pathology, Harvard Medical School
Associate Pathologist, Laboratory for Molecular Medicine /
Partners Healthcare Center for Personalized Genetic Medicine
Department of Pathology, Brigham and Women's Hospital
Visiting Scientist, Laboratory of Harvey Lodish, PhD
Whitehead Institute for Biomedical Research
9 Cambridge Center, Room 613
Cambridge, MA 02142
Phone 617 435 1001
Email ckunst at wi.mit.edu<mailto:ckunst at wi.mit.edu>, ckunst at partners.org<mailto:ckunst at partners.org>




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