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<div><b><span style="font-size: 18pt; font-family: Arial; color: rgb(38, 36, 83); ">9/11/2013
Fall 2013
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<p class="MsoNormal"><b><span style="font-size: 18pt; font-family: Arial; color: rgb(38, 36, 83); ">Department/Lab/Center: Whitehead Institute / Biology<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size: 18pt; font-family: Arial; color: rgb(38, 36, 83); ">Biology
Faculty Supervisor: Prof. Harvey Lodish<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Project Title: </span></b><span style="font-size: 16pt; font-family: Arial; ">Mechanisms of Mitochondrial Oxidative Stress Signaling
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Project Description:</span></b><span style="font-size: 16pt; font-family: Arial; "> Oxidative stress and mitochondrial dysfunction are linked to numerous diseases. The goal of this
UROP project is to determine the role of metabolites and certain drugs in modulating oxidative stress signaling. The student will have the opportunity to learn mammalian cell culture and purification techniques and Western blotting with a possible extension
to other techniques such as flow cytometry and confocal imaging. The student is expected to formally present the research in lab meeting. A senior post-doc in the lab will supervise the project.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Prerequisites:</span></b><span style="font-size: 16pt; font-family: Arial; "> Prior laboratory experience in molecular biology is desired. The project is especially suited for biology
majors in their senior year. Attention to detail and ability to keep an organized record of observations and results are essential.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Time:</span></b><span style="font-size: 16pt; font-family: Arial; "> At least one full day and a subsequent half-day per week are required to perform the experiments. The successful
applicant will commence the UROP over the fall semester and be encouraged to continue over the IAP period and subsequent semester with the possibility to transition into a full-time research technician position.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Contact: </span></b><span style="font-size: 16pt; font-family: Arial; ">Interested applicants should send a CV to Heide Christine Patterson, MD (<a href="mailto:ckunst@wi.mit.edu">ckunst@wi.mit.edu</a>).<o:p></o:p></span></p>
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<p class="MsoNormal"><b><span style="font-size: 18pt; font-family: Arial; color: rgb(38, 36, 83); ">9/11/2013
Fall 2013
<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size: 18pt; font-family: Arial; color: rgb(38, 36, 83); ">Department/Lab/Center: Whitehead Institute / Biology<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size: 18pt; font-family: Arial; color: rgb(38, 36, 83); ">Biology
Faculty Supervisor: Prof. Harvey Lodish<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Project Title: </span></b><span style="font-size: 16pt; font-family: Arial; ">Mechanisms of Mitochondrial Oxidative Stress Signaling
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Project Description:</span></b><span style="font-size: 16pt; font-family: Arial; "> Oxidative stress and mitochondrial dysfunction are linked to numerous diseases. The goal of this
UROP project is to determine whether the signaling domain of a mitochondrial protein promotes signaling as part of a larger project characterizing the mechanisms of mitochondrial oxidative stress signaling. The student will have the opportunity to learn molecular
biology, cell culture and transfection techniques as well as Western blotting. The student will be trained in critically evaluating the data and is expected to formally present the research in lab meeting. A senior post-doc in the lab will supervise the project.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Prerequisites:</span></b><span style="font-size: 16pt; font-family: Arial; "> Prior molecular biology experience is desired but not required. Attention to detail and ability to keep
an organized record of observations and results are essential.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Time:</span></b><span style="font-size: 16pt; font-family: Arial; "> A time commitment of at least 8 hours per week during the semester is expected. The successful applicant will commence
the UROP over the fall semester and be encouraged to continue over the IAP period and subsequent semesters.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size: 16pt; font-family: Arial; ">Contact: </span></b><span style="font-size: 16pt; font-family: Arial; ">Interested applicants should send a CV to Heide Christine Patterson, MD (<a href="mailto:ckunst@wi.mit.edu">ckunst@wi.mit.edu</a>).<o:p></o:p></span></p>
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<div>*****************</div>
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<div>Heide Christine Patterson, MD</div>
<div>Instructor in Pathology, Harvard Medical School</div>
<div>Associate Pathologist, Laboratory for Molecular Medicine /</div>
<div>Partners Healthcare Center for Personalized Genetic Medicine</div>
<div>Department of Pathology, Brigham and Women's Hospital</div>
<div>Visiting Scientist, Laboratory of Harvey Lodish, PhD</div>
<div>Whitehead Institute for Biomedical Research</div>
<div>9 Cambridge Center, Room 613</div>
<div>Cambridge, MA 02142</div>
<div>Phone 617 435 1001</div>
<div>Email <a href="mailto:ckunst@wi.mit.edu">ckunst@wi.mit.edu</a>, <a href="mailto:ckunst@partners.org">ckunst@partners.org</a> </div>
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