[bioundgrd] Fwd: Summer Intern Position at Genentech Inc: South San Francisco

[MacKenzie Outlund]

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*Position Details:*



Background:  Human embryonic stem cells (hESCs) and induced pluripotent stem
cells (iPSCs) provide remarkable cellular platforms to better understand
human hematopoiesis and to develop clinically applicable hematopoietic
cell-based therapies.  Over the last decade, hESCs have been utilized to
characterize molecular and cellular mechanisms underpinning the
differentiation of hematopoietic progenitors and mature, functional
hematopoietic cells.



Project:

i) Directed differentiation of human stem cells into the hematopoietic and
mesenchymal stem cell lineages

ii) Development of in vitro cultures of hematopoietic & mesenchymal stem
cells and their different progenitors for use in bone marrow toxicity assays



Project Details:  The identification and use of specific cytokine
combinations which support stem cell proliferation and differentiation have
been developed which allows the ex vivo generation of mesenchymal &
hematopoietic cells for bone marrow toxicity evaluation.  The major work in
this project will involve successful derivation of hematopoietic &
mesenchymal stem cells and further expansion of different lineages of
hematopoietic cells requiring the establishment of well-controlled,
reproducible and reliable culture conditions.



Contact:

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Hirdesh Uppal, DVM, PhD.

Development Sciences,

Genentech, Inc.

1 DNA Way, MS#59

South San Francisco, CA 94080

Email: hirdeshu at gene.com

Tel: 650-225-7180
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