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<p class="MsoNormal"><b><u><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial;font-weight:bold">Position Details:</span></font></u></b></p>

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<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Background:  Human embryonic stem cells (hESCs) and
induced pluripotent stem cells (iPSCs) provide remarkable cellular platforms to
better understand human hematopoiesis and to develop clinically applicable hematopoietic
cell-based therapies.  Over the last decade, hESCs have been utilized to
characterize molecular and cellular mechanisms underpinning the differentiation
of hematopoietic progenitors and mature, functional hematopoietic cells.</span></font></p>

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<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Project:  </span></font></p>

<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">i) Directed differentiation of human stem cells into the
hematopoietic and mesenchymal stem cell lineages </span></font></p>

<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">ii) Development of in vitro cultures of hematopoietic &amp;
mesenchymal stem cells and their different progenitors for use in bone marrow
toxicity assays</span></font></p>

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<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Project Details:  The identification and use of
specific cytokine  combinations which support stem cell proliferation and
differentiation have been developed which allows the ex vivo generation of
mesenchymal &amp; hematopoietic cells for bone marrow toxicity evaluation. 
The major work in this project will involve successful derivation of
hematopoietic &amp; mesenchymal stem cells and further expansion of different
lineages of hematopoietic cells requiring the establishment of well-controlled,
reproducible and reliable culture conditions.   </span></font></p>

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<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Contact:</span></font></p>

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<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Hirdesh Uppal, DVM, PhD.</span></font></p>

<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Development Sciences,</span></font></p>

<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Genentech, Inc.</span></font></p>

<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">1</span></font><font face="Arial"><span style="font-family:Arial"> DNA Way, MS</span></font><font face="Arial"><span style="font-family:Arial">#59</span></font></p>



<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">South San
  Francisco</span></font><font face="Arial"><span style="font-family:Arial">, CA 94080</span></font><font face="Arial"><span style="font-family:Arial"></span></font></p>

<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Email: <a href="mailto:hirdeshu@gene.com" target="_blank">hirdeshu@gene.com</a></span></font></p>

<p class="MsoNormal"><font size="2" face="Arial"><span style="font-size:10.0pt;font-family:Arial">Tel: 650-225-7180</span></font></p>

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