[bioundgrd] Summer UROP availability in Page Lab

[Janice Chang]

Summer UROP projects available in Professor David Page's lab. 
Contact Anna Welland, info below if you are interested.


Summer 2007
UROP Department/Lab/Center: Whitehead Institute
Faculty Supervisor: David Page

Project Title: Investigating genes involved in infertility and 
testicular cancer

Project Description: Our lab focuses its studies on how the mammalian 
embryo becomes male or female.  We are particularly interested in how 
this fundamental decision is made in the germline of mice, and how 
errors involving this decision can result in formation of testicular 
cancer.  We have identified several genes that are involved in this 
decision process as well as in testicular cancer that warrant further 
characterization.

Project 1: The early development of female germ cells is not well 
understood in mammals.  We have identified several candidate genes 
whose expression suggests roles in this process.  We are interested 
in investigating the expression and regulation of these genes in the 
mouse using real-time RT-PCR and in situ hybridization.

Project 2: There is currently no established mouse model for 
seminoma, the most common form of testicular cancer in humans.  We 
have established a mouse tumor model, which may resemble this type of 
cancer.  We are interested in comparing the phenotype of these tumors 
to that of human seminomas.  Techniques involved will include 
real-time RT-PCR, immunohistochemistry, and cell culture.

Prerequisites: We are looking for enthusiastic students for the 
summer possibly extending into the fall semester.  Biology 
coursework, including 7.02, and a willingness to work with mice are 
required.  Prior laboratory experience in molecular biology is highly 
recommended. Funding will not be provided, but student can bring 
his/her funding to lab. Credit may be provided.

Contact: Anna Welland at welland at wi.mit.edu with a resume/CV and a 
brief statement of interest.
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