<!doctype html public "-//W3C//DTD W3 HTML//EN">
<html><head><style type="text/css"><!--
blockquote, dl, ul, ol, li { padding-top: 0 ; padding-bottom: 0 }
--></style><title>Summer UROP availability in Page
Lab</title></head><body>
<div><font color="#000000">Summer UROP projects available in Professor
David Page's lab. Contact Anna Welland, info below if you are
interested.</font></div>
<div><font color="#000000"><br></font></div>
<div><font color="#000000"><br></font></div>
<div><font color="#000000">Summer 2007<br>
UROP Department/Lab/Center: Whitehead Institute<br>
Faculty Supervisor: David Page<br>
<br>
<b>Project Title:</b> Investigating genes involved in infertility and
testicular cancer<br>
<br>
<b>Project Description:</b> Our lab focuses its studies on how the
mammalian embryo becomes male or female. We are particularly
interested in how this fundamental decision is made in the germline of
mice, and how errors involving this decision can result in formation
of testicular cancer. We have identified several genes that are
involved in this decision process as well as in testicular cancer that
warrant further characterization.<br>
<br>
<b>Project 1:</b> The early development of female germ cells is not
well understood in mammals. We have identified several candidate
genes whose expression suggests roles in this process. We are
interested in investigating the expression and regulation of these
genes in the mouse using real-time RT-PCR and<i> in situ</i>
hybridization.<br>
<br>
<b>Project 2:</b> There is currently no established mouse model for
seminoma, the most common form of testicular cancer in humans.
We have established a mouse tumor model, which may resemble this type
of cancer. We are interested in comparing the phenotype of these
tumors to that of human seminomas. Techniques involved will
include real-time RT-PCR, immunohistochemistry, and cell culture.<br>
<br>
<b>Prerequisites:</b> We are looking for enthusiastic students for the
summer possibly extending into the fall semester. Biology
coursework, including 7.02, and a willingness to work with mice are
required. Prior laboratory experience in molecular biology is
highly recommended. Funding will not be provided, but student can
bring his/her funding to lab. Credit may be provided.</font></div>
<div><font color="#000000"><br></font></div>
<div><font color="#000000"><b>Contact:</b> Anna Welland at
welland@wi.mit.edu with a resume/CV and a brief statement of
interest.</font></div>
<div><font color="#000000"><br></font></div>
</body>
</html>