[OWW-Discuss] Why $0.00 Is the Future of Business

[Dan Bolser]

On 26/02/2008, Austin Che <austin at csail.mit.edu> wrote:
>
>     On slashdot:
>     http://www.wired.com/techbiz/it/magazine/16-03/ff_free?currentPage=all
>     http://slashdot.org/article.pl?sid=08/02/26/0335227
>

That reminds me...

openfree Genomics.org

http://genomics.org/index.php/Main_Page

"$0 Genomics" Project Launched on-line.  Please sign!

The first contributions of 'complete' human genome-typing data sets
have already been contributed to this openfree community. I discovered
my friend shouldn't drink too much coffee! (He has rs762551 type
"AC"... see below).



Metabolism and heart attack
Journal JAMA
Study Size
Replications    None
Contrary Studies        None
Ethnicities     European
Marker  rs762551

Caffeine is primarily metabolized by the enzyme cytochrome P450 1A2
(CYP1A2) in the liver. The SNP rs762551 causes a change in this enzyme
that may significantly affect the rate of caffeine metabolism. In this
study, people with the slower version of the CYP1A2 enzyme had
increased risk of a non-fatal heart attack when they increased their
coffee intake. The study found that slow metabolizers who drank more
than two to three cups of coffee a day had a significant increase in
their risk of non-fatal heart attack compared with fast metabolizers,
who may have even reduced their risk when they drank coffee.

Who     Genotype        What It Means
Greg Mendel (Dad)       AA      Fast caffeine metabolizer.
Lilly Mendel (Mom)      AC      Slow caffeine metabolizer: drinking coffee
increased subjects' heart attack risk.
       CC      Slow caffeine metabolizer: drinking coffee increased subjects'
heart attack risk.

Citations
Cornelis MC et al. (2006). "Coffee, CYP1A2 genotype, and risk of
myocardial infarction." JAMA 295(10):1135-41.





>     I think the 'penny gap' is particularly interesting. There's a
>     huge difference in market and psychology between charging nothing
>     and any amount, even one penny.
>
>     There's also an interesting grouping of 'free' business models. It
>     seems like OWW will need to pick one of them to sustain
>     itself. Here's how I applied them to OWW:
>
>     Freemium: main wiki is free, we charge for private wikis or
>     premium services
>
>     Advertising: ads on the wiki, paid listings
>
>     Cross-subsidies: We use a free wiki to sell something else (OWW
>     t-shirts? OWW kits?)
>
>     Zero marginal cost: the cost of hosting/running the site reach
>     zero so we don't need to get any money.
>
>     Labor exchange: Make money off the labor generated by OWW
>     users. For example, sell the rights to publish OWW protocols to
>     books.
>
>     Gift economy: rely on altruism.
>
>
>  --
>  Austin Che           <austin at csail.mit.edu>          (617)253-5899
>  _______________________________________________
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>  discuss at openwetware.org
>  http://mailman.mit.edu/mailman/listinfo/oww-discuss
>


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