[MOS] 5/24 - Modern Optics and Spectroscopy Virtual Seminar with Gerwin Puppels (RiverD)

[Christine Brooks]

There will be a virtual Modern Optics and Spectroscopy Seminar held next Tuesday, May 24 at 12pm. A short Q&A segment will immediately follow the conclusion of the seminar.

Zoom link: https://mit.zoom.us/j/98625465964?pwd=SU0rZ0syc1JUL2RBenZRdE8weE5PQT09
Password: 224533
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Gerwin Puppels
RiverD International B.V.

“In vivo skin characterisation and skin penetration analysis by confocal Raman spectroscopy.”

The skin is the barrier between the body and the outside world. The total skin surface area of the adult body is about 2 m2. It prevents uncontrolled loss of water and keeps chemicals and microorganisms out.  However, until now the ability to actually measure and quantify how well this barrier works has eluded us. Current methods are indirect, have reproducibility issues, are invasive and/or use conditions that are far from actual in vivo conditions.  They leave a lot to wish for.

This poses a problem for topical product development in personal care industry and pharmaceutical industry. The absence of a reliable method which non-invasively determines the penetration and permeation of a topically applied product, also creates a hurdle for so-called bioequivalence studies, which are required to bring a generic pharmaceutical products to market.
Various (vibrational spectroscopic) techniques are being developed to address this problem.

This presentation will discuss quantitative analysis of skin penetration of a topically applied material by in vivo confocal Raman spectroscopy, It will address methodological aspects and limits of detection, as well as illustrate how it can be used to optimize product formulation, and how much the penetration rate of a product can differ between different parts of the body.

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Christine Brooks
Administrative Assistant
Massachusetts Institute of Technology
Department of Chemistry
77 Massachusetts Ave, 6-333
Cambridge, MA 02139
p: 617.253.7239
e: cbrooks at mit.edu<mailto:cbrooks at mit.edu>

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