[MOS] Tomorrow 11/30 - Modern Optics and Spectroscopy Virtual Seminar with Ben Schuler (University of Zurich)

[Christine Brooks]

There will be a virtual Modern Optics and Spectroscopy Seminar held tomorrow, November 30 at 12pm. A short Q&A segment will immediately follow the conclusion of the seminar.

Zoom link: https://mit.zoom.us/j/95781758126?pwd=ZGgxbnF5ZFZwOU9BNnFubDcyNWw1Zz09
Password: 729315
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Ben Schuler
University of Zurich (Switzerland)

“Probing the Dynamics and Interaction Mechanisms of
Intrinsically Disordered Proteins with Single-Molecule Spectroscopy”

The functions of proteins have traditionally been linked to their well-defined three-dimensional, folded structures. It is now clear, however, that many proteins perform essential functions without being folded. Quantifying the highly dynamic and conformationally diverse ensembles of such unfolded or ‘intrinsically disordered’ proteins (IDPs) is an important aspect of understanding their functional mechanisms. Single-molecule spectroscopy is ideally suited for investigating these systems. I will illustrate how the combination of single-molecule Förster resonance energy transfer (FRET) with nanosecond correlation spectroscopy, microfluidic mixing, and other methods can be used to probe the intra- and intermolecular distance distributions, reconfiguration dynamics, and interactions over a wide range of timescales, and in heterogeneous environments, including live cells.

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Christine Brooks
Administrative Assistant
Massachusetts Institute of Technology
Department of Chemistry
77 Massachusetts Ave, 6-333
Cambridge, MA 02139
p: 617.253.7239
e: cbrooks at mit.edu<mailto:cbrooks at mit.edu>

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