[MOS] 2/12 - Modern Optics and Spectroscopy Seminar with YongKeun Paul Park (KAIST)

[Christine Brooks]

There will be a Modern Optics and Spectroscopy Seminar held next Tuesday, February 12 at 12pm in 1-190

**Please note location**

YongKeun (Paul) Park
KAIST, Korea

“Holotomography and artificial intelligence:
from label-free live cells imaging to medical applications exploiting cell phenotypes”


Holotomography (HT) is a 3D quantitative phase imaging technique, which uses laser interferometry to provide the 3-D label-free imaging of live cells and tissues. As an optical analogous to X-ray computed tomography (CT), HT measures multiple 2-D holograms of a sample with various illumination angles, from which the 3-D refractive index (RI) distribution of the sample is reconstructed by inversely solving the wave equation. Unlike conventional fluorescence-based microscopy, HT provides label-free imaging capability. Without any fixation or labeling, 3-D images of live cells can be obtained with high spatial resolution (down to 110 nm). Furthermore, HT provides quantitative imaging capability: RI maps of a cell are precisely and quantitative measured, from which various cellular analysis can be followed.
 In this seminar, we will present the principles of HT and applications. In particular, we will discuss the potentials of HT in medical applications, including the study of CAR-T cells interacting with target cancer cells and rapid label-free identification of cells using 3D phenotypes.

References
1. YK Park et al., Quantitative phase imaging in biomedicine, Nature Photonics, 12, 578–589 (2018)
2. Y Jo et al., Quantitative Phase Imaging and Artificial Intelligence: A Review, IEEE Journal of Selected Topics in Quantum Electronics, 25(1), 6800914 (2019)


Refreshments will be served immediately following the seminar!


Christine Brooks
Administrative Assistant
Massachusetts Institute of Technology
Department of Chemistry
77 Massachusetts Ave, 6-333
Cambridge, MA 02139
p: 617.253.7239
e: cbrooks at mit.edu<mailto:cbrooks at mit.edu>

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