[MOS] 12/5 (Tomorrow) - Modern Optics and Spectroscopy Seminar with Rizal Hariadi (Arizona State University)

[Christine Brooks]

There will be a Modern Optics and Spectroscopy Seminar held tomorrow, December 5 at 12pm in 34-401:

Rizal F. Hariadi
Department of Physics, Biodesign Institute
Arizona State University

Protein and DNA origami nanoarrays: from dissecting molecular machines to democratizing digital diagnostics

Abstract – The functions of complex biological systems arise, in part, from the organization and subtle interactions of biomolecules. DNA origami, in combination with conjugation strategies, offers a unique opportunity to organize biomolecules for applications in biophysics and diagnostics. In this talk, I will present our latest research demonstrating the exquisite positional control of DNA origami technology across multiple length scales. In the first part of my talk, I will show two DNA-nanostructure-guided protein arrays for dissecting collective behaviors of molecular machines consisting of 100-nm-sized rectangular DNA origami nanostructures and tens-of-micron-long DNA nanotubes, patterned with myosin motors. These studies uncover elegant engineering principles for designing force sensors and molecular transporters on complex landscapes. In the second half of the talk, I will present some recent results obtained in collaboration with Ashwin Gopinath and Paul Rothemund on the development of lithography-free cm-scale DNA origami nanoarrays. Finally, I will conclude with a discussion on the transformative potential and future directions of protein and DNA nanoarrays, including high-throughput single-molecule biophysics and low-cost digital diagnostics that target minuscule concentrations of DNA.



Refreshments will be served immediately following the seminar


Christine Brooks
Administrative Assistant
Massachusetts Institute of Technology
Department of Chemistry
77 Massachusetts Ave, 6-333
Cambridge, MA 02139
p: 617.253.7239
e: cbrooks at mit.edu<mailto:cbrooks at mit.edu>

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