[MOS] March 2, 2010

[Zina Queen]

Seminar on

Modern Optics and Spectroscopy

Foray into high resolution label-free chemical imaging

Mikhail Slipchenko,
Purdue University

Tuesday, March 2, 2010

12:00 - 1:00 p.m.

Chemical imaging is an emerging analytical tool which offers dynamic, 
non-invasive, and compositional analysis of chemically heterogeneous 
materials. To overcome the low signal level problem encountered in 
Raman chemical imaging, coherent Raman scattering (CRS) microscopy 
techniques have been developed. Here we describe latest advances in 
high-speed high-resolution chemical imaging based on coherent 
anti-Stokes Raman scattering (CARS) and stimulated Raman scattering 
(SRS) modalities. Specific examples will be presented including 
imaging of lipid bodies of cultured cells, explanted tissues, live 
animals as well as chemical imaging of pharmaceutical solid dosage 
forms. The preliminary results on development of optically 
heterodyned Raman-induced Kerr-effect (OHRIKE) modality will be 
discussed.



Grier Room, MIT Bldg 34-401
Refreshments served after the lecture
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