[MOS] CIMIT Forum Tuesday April 17, 2007: Lester Wolfe Workshop in Laser Biomedicine: Optical Methods in Breast Cancer

[Zina Queen]

Please Join Us at the CIMIT Forum / Lester Wolfe Workshop...

Tuesday, April 17, 2007
4:00-6:00pm
REFRESHMENTS at 3:30pm
Location: Massachusetts General Hospital, Richard 
B. Simches Research Center, Room 3110, 185 
Cambridge St, Boston
Directions to MGH and Richard B. Simches Research 
Center: <http://www.cimit.org/directions.html> 
http://www.cimit.org/directions.html
Map of MGH Campus: 
<http://www.cimit.org/documents/SimchesMap.pdf> 
http://www.cimit.org/documents/SimchesMap.pdf
Note: You will need to check in with Security 
upon entering the Simches Research Center. PHS 
employees, please bring your identification 
badges. All others will be provided temporary 
badges.

Lester Wolfe Workshop in Laser Biomedicine: Optical Methods in Breast Cancer

Early diagnosis, management and therapy of breast 
cancer are important problems, and there is 
interesting science as well. Optical methods hold 
much promise. The Workshop will begin with an 
overview, to be followed by presentations of 
optical methodologies in forefront areas. 
Sponsored by the MIT G.R. Harrison Spectroscopy 
Laboratory, Massachusetts General Hospital 
Wellman Center for Photomedicine; Harvard-MIT 
Division of Health Sciences and Technology and 
Center for Integration of Medicine and Innovative 
Technology (CIMIT). Click here to read about 
Lester Wolfe: 
<http://web.mit.edu/spectroscopy/events/wolfe.html> 
http://web.mit.edu/spectroscopy/events/wolfe.html

Moderator: Michael Hamblin, PhD, Associate 
Professor, Wellman Center for Photomedicine, MGH
Introduction and Clinical Overview
Barbara L. Smith, MD, PhD, Director, Breast 
Program of the Cancer Center and Co-Director of 
the Women’s Cancers Program, Massachusetts 
General Hospital; Assistant Professor of Surgery, 
Harvard Medical School and MGH; Chief of Breast 
Surgical Services, Gillette Centers for Women’s 
Cancers, Dana-Farber Cancer Institute

Shedding Light on Breast Cancer: Advances in 
Optical Spectroscopy Diagnosis of Breast Cancer
Maryann Fitzmaurice, MD, PhD, Associate Professor 
of Pathology and Oncology, Case Western Reserve 
University
Despite recent clinical advances, there remain 
challenges to early diagnosis and effective 
therapy of breast cancer. Among these are 
mammographic “false positives” (mammographically 
suspect lesions that are benign on biopsy) and 
operative “false negatives” (positive margins 
missed at breast cancer surgery that necessitate 
re-operation for complete resection). Optical 
spectroscopy holds promise for both improving the 
accuracy of breast cancer diagnosis and enabling 
breast cancer diagnosis to be made in a less 
invasive and more timely fashion. Recent work on 
the optical spectroscopy of breast cancer will be 
reviewed, and results presented for ex vivo 
pre-clinical studies using a multi-modality 
technique that combines diffuse reflectance, 
fluorescence and Raman spectroscopy to provide 
more robust spectroscopic breast cancer diagnosis.

Breast Imaging and Characterization with Diffuse Optics
Arjun Yodh, PhD, James M. Skinner Professor of 
Science, Department of Physics & Astronomy, 
University of Pennsylvania
This talk is oriented towards functional imaging 
and spectroscopy of breast cancer. Professor 
Arjun Yodh will focus on several recent studies, 
summarize the tumor contrast results obtained in 
a pilot clinical investigation employing diffuse 
optical tomography (DOT), and discuss the next 
generation instrument. He will present first 
in-vivo fluorescence diffuse optical tomography 
(FDOT) of breast cancer, describe the measurement 
of tumor blood flow and oxygenation of breast 
cancer during chemotherapy, and, if time permits, 
present multi-modal measurements combining DOT 
with positron emission tomography (PET).

Intra-operative Optical Biopsy of Breast Cancer
Stephen Boppart, MD, PhD, Director, Mills Breast 
Cancer Institute, Carle Foundation Hospital; 
Associate Professor, Electrical Engineering, 
Bioengineering, and Medicine, University of 
Illinois at Urbana-Champaign

Traditionally, the microscopic evaluation and 
diagnosis of tissue biopsy specimens has occurred 
remote from the point-of-care, since tissue 
processing, sectioning, and staining must be 
performed. Coherent optical imaging techniques 
such as optical coherence tomography (OCT) enable 
real-time intra-operative visualization of tissue 
architecture at cellular resolution, with the 
potential to perform volumetric microscopy and 
computer-automated classification over large 
regions. OCT has been used intraoperatively to 
assess margin status of lumpectomy specimens, and 
to assess lymph nodes for evidence of metastases. 
Fiber-optic beam delivery within needle probes 
facilitates guiding needle biopsies of breast 
masses. These methods enable real-time, 
point-of-care feedback during surgical procedures 
and interventions in the treatment of breast 
cancer.

Click here to learn more about the CIMIT Forum: 
<file://www.cimit.org/forum/current.html> 
www.cimit.org/forum/current.html

Note: There is no registration required to attend the weekly CIMIT Forum.

CIMIT (Center for Integration of Medicine and 
Innovative Technology) is a catalyst for the 
application of technology to healthcare. The 
focus is to bring together scientists and 
engineers working at the frontiers of high 
technology with clinicians who are at the 
forefront of medicine. The goal of the CIMIT 
Forum is to promote the exchange of ideas and 
information between diverse communities and to 
provide an arena where interdisciplinary 
discussion can lead to breakthroughs in 
biomedical engineering and ultimately patient 
care. Dialogue is an important part of opening 
doors for education and collaboration. The 
audience is a diverse group of practitioners and 
researchers, including clinicians, engineers, 
educators, scientists, administrators and 
students. For more information about Tuesday's 
Forum, visit 
<file://www.cimit.forum/current.html> 
www.cimit.forum/current.html or contact DeAnna 
Grosbaum, dgrosbaum at partners.org, 617-726-0797.
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