[CSBi-events] CSB seminar Friday 11/6 - Dr. Roy Kishony

[CSBi events]

Fall 2009 Seminar Series on Computational and Systems Biology

Friday, November  6, 2009

3:00 pm - 4:00 pm

Room 32-463D

 

Presenting:

Drug interactions and their impact on the evolution of resistance

                              

Professor Roy Kishony

Department of Systems Biology

Harvard Medical School

 

The application of antibiotics is hindered by a well-known "catch-22": The
use of a drug promotes the emergence and spread of drug-resistant mutants
that ultimately render it ineffective. While certain combination therapies
are known to be more effective than single drugs, the impact of such
treatments on the evolution of drug resistance is unclear. I will describe a
combined theoretical-experimental approach to understand drug interactions
and their effect on the evolution of resistance. Our results demonstrate how
we can understand the genetic source of drug interactions and how drug
interactions can be used to diminish and even invert the selection pressure
for antibiotic resistance. 

 

 Light refreshments to be served at 2:45 pm 

 Host: Jeff Gore (jeffgore at gmail.com), Department of Physics

 

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