[CSBi-events] CSB/Biophysics Seminar next Friday (Fri, 11/13) -- Prof. Johan Paulsson

[CSBi events]

Fall 2009 Seminar Series on Computational and Systems Biology

Friday, November  13, 2009

3:00 pm - 4:00 pm

Room 32-463D

 

Presenting:

Understanding non-genetic heterogeneity in cells 

                              

Professor Johan Paulsson

Department of Systems Biology

Harvard Medical School

 

Life in single cells is dictated by chance: Reactions that involve small
numbers of molecules generate spontaneous fluctuations that enslave all
dependent processes. Such 'noise' can randomize developmental pathways,
disrupt cell cycle control or force metabolites away from their optimal
levels. It can also be exploited for advantageous heterogeneity or even for
more deterministic control. I will discuss new concepts and analytical
frameworks that enable us to analyze such processes, addressing many of the
complications and challenges in cellular dynamics while at the same time
promoting intuition and facilitating comparisons with experiments. The
principles discussed will be illustrated with homeostatic feedback control,
partitioning at cell division, stochastic gene expression, multimerization,
and small RNAs. 

 

 Light refreshments to be served at 2:45 pm

 Host: Alexander van Oudenaarden ( <mailto:avo1 at mit.edu> avo1 at mit.edu),
Department of Physics and Biology

 

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