[CSBi-events] CSBi Seminar - Jonathan Widom - Feb 29

[CSBi events]

Spring 2008 Seminar Series on Computational and Systems Biology
Friday, February 29, 2008
3:00 pm – 4:00 pm
Room 3-270

Presenting:
Dr. Jonathan Widom
Department of Biochemistry, Molecular Biology and Cell Biology and  
Department of Chemistry, Northwestern University

Title: The Genomic Code for Nucleosome Positioning
Abstract: Eukaryotic genomes encode an additional layer of genetic  
information, superimposed on top of the regulatory and coding  
information that controls the organization of the genomic DNA into  
arrays of nucleosomes.  We have developed a partial ability to read  
this nucleosome positioning code and predict the in vivo locations of  
nucleosomes, using two independent approaches.  One approach is based  
on a statistical profile of natural nucleosome DNAs, the other on a  
dinucleotide mechanics model derived from X-ray crystallographic  
studies of non-nucleosomal protein-DNA complexes. Our results suggest  
that genomes utilize the nucleosome positioning code to facilitate  
specific chromosome functions including to delineate functional  
versus nonfunctional binding sites for key gene regulatory proteins,  
and to define the next higher level of chromosome structure itself.

Light refreshments to be served at 2:45 pm

Host:
Paul Wiggins, Whitehead Institute
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