From csbi-events at mit.edu Wed Feb 6 10:34:33 2008 From: csbi-events at mit.edu (CSBi events) Date: Wed, 6 Feb 2008 10:34:33 -0500 Subject: [CSBi-events] TOMORROW - CSBi Seminar - Dr. Uri Alon Message-ID: <375BB884-1177-42EC-B41A-B8AB6C041FC0@mit.edu> TOMORROW Spring 2008 Seminar Series on Computational and Systems Biology Friday, February 8, 2008 3:00 pm ? 4:00 pm Room 3-270 Presenting: Dr. Uri Alon Department of Molecular Cell Biology and Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel Title: Design Principles of Complex Systems Abstract: Transcriptional networks are made of a collection of recurring interaction patterns known as network motifs. The same handful of basic circuit elements seems to appear across organisms. Network motifs are thought to be selected because they carry out specific dynamical functions. We will describe high-resolution experiments on living cells that demonstrate several such functions of network motifs, including sign-sensitive delays, speedup of network response, pulse generation and temporal programs of gene expression. We will also describe network motifs in other biological networks, including signaling and neuronal networks. [See U. Alon, Network motifs: theory and experimental approaches, Nat. Rev. Genetics 8, 450-461 (2007).] Light refreshments to be served at 2:45 pm Hosts: Dr. Alexander van Oudenaarden, Department of Physics Mei Lyn Ong, Graduate Student, Computational and Systems Biology -------------- next part -------------- An HTML attachment was scrubbed... URL: http://mailman.mit.edu/pipermail/csbi-events/attachments/20080206/f9f3b644/attachment.htm From csbi-events at mit.edu Wed Feb 20 10:10:36 2008 From: csbi-events at mit.edu (CSBi events) Date: Wed, 20 Feb 2008 10:10:36 -0500 Subject: [CSBi-events] CSBi Seminar - Jonathan Widom - Feb 29 Message-ID: <37F7BAAE-E668-45FC-88E4-1B2C87D39B00@mit.edu> Spring 2008 Seminar Series on Computational and Systems Biology Friday, February 29, 2008 3:00 pm ? 4:00 pm Room 3-270 Presenting: Dr. Jonathan Widom Department of Biochemistry, Molecular Biology and Cell Biology and Department of Chemistry, Northwestern University Title: The Genomic Code for Nucleosome Positioning Abstract: Eukaryotic genomes encode an additional layer of genetic information, superimposed on top of the regulatory and coding information that controls the organization of the genomic DNA into arrays of nucleosomes. We have developed a partial ability to read this nucleosome positioning code and predict the in vivo locations of nucleosomes, using two independent approaches. One approach is based on a statistical profile of natural nucleosome DNAs, the other on a dinucleotide mechanics model derived from X-ray crystallographic studies of non-nucleosomal protein-DNA complexes. Our results suggest that genomes utilize the nucleosome positioning code to facilitate specific chromosome functions including to delineate functional versus nonfunctional binding sites for key gene regulatory proteins, and to define the next higher level of chromosome structure itself. Light refreshments to be served at 2:45 pm Host: Paul Wiggins, Whitehead Institute -------------- next part -------------- An HTML attachment was scrubbed... URL: http://mailman.mit.edu/pipermail/csbi-events/attachments/20080220/e9eebec2/attachment.htm From csbi-events at mit.edu Fri Feb 29 09:20:31 2008 From: csbi-events at mit.edu (CSBi events) Date: Fri, 29 Feb 2008 09:20:31 -0500 Subject: [CSBi-events] TODAY - CSBi Seminar - Jonathan Widom Message-ID: TODAY! Spring 2008 Seminar Series on Computational and Systems Biology Friday, February 29, 2008 3:00 pm ? 4:00 pm Room 3-270 Presenting: Dr. Jonathan Widom Department of Biochemistry, Molecular Biology and Cell Biology and Department of Chemistry, Northwestern University Title: The Genomic Code for Nucleosome Positioning Abstract: Eukaryotic genomes encode an additional layer of genetic information, superimposed on top of the regulatory and coding information that controls the organization of the genomic DNA into arrays of nucleosomes. We have developed a partial ability to read this nucleosome positioning code and predict the in vivo locations of nucleosomes, using two independent approaches. One approach is based on a statistical profile of natural nucleosome DNAs, the other on a dinucleotide mechanics model derived from X-ray crystallographic studies of non-nucleosomal protein-DNA complexes. Our results suggest that genomes utilize the nucleosome positioning code to facilitate specific chromosome functions including to delineate functional versus nonfunctional binding sites for key gene regulatory proteins, and to define the next higher level of chromosome structure itself. Light refreshments to be served at 2:45 pm Host: Paul Wiggins, Whitehead Institute -------------- next part -------------- An HTML attachment was scrubbed... URL: http://mailman.mit.edu/pipermail/csbi-events/attachments/20080229/2d8a1c70/attachment.htm